English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Coupling of Active Motion and Advection Shapes Intracellular Cargo Transport

Trong, P. K., Guck, J., & Goldstein, R. E. (2012). Coupling of Active Motion and Advection Shapes Intracellular Cargo Transport. PHYSICAL REVIEW LETTERS, 109(2): 028104. doi:10.1103/PhysRevLett.109.028104.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0004-B3A2-A Version Permalink: http://hdl.handle.net/21.11116/0000-0004-B3A3-9
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Trong, Philipp Khuc1, Author
Guck, Jochen2, Author              
Goldstein, Raymond E.1, Author
Affiliations:
1external, ou_persistent22              
2External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Intracellular cargo transport can arise from passive diffusion, active motor-driven transport along cytoskeletal filament networks, and passive advection by fluid flows entrained by such cargo-motor motion. Active and advective transport are thus intrinsically coupled as related, yet different representations of the same underlying network structure. A reaction-advection-diffusion system is used here to show that this coupling affects the transport and localization of a passive tracer in a confined geometry. For sufficiently low diffusion, cargo localization to a target zone is optimized either by low reaction kinetics and decoupling of bound and unbound states, or by a mostly disordered cytoskeletal network with only weak directional bias. These generic results may help to rationalize subtle features of cytoskeletal networks, for example as observed for microtubules in fly oocytes.

Details

show
hide
Language(s): eng - English
 Dates: 2012
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1103/PhysRevLett.109.028104
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: PHYSICAL REVIEW LETTERS
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA : AMER PHYSICAL SOC
Pages: - Volume / Issue: 109 (2) Sequence Number: 028104 Start / End Page: - Identifier: ISSN: 0031-9007