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  Critical review: cellular mechanobiology and amoeboid migration

Guck, J., Lautenschlaeger, F., Paschke, S., & Beil, M. (2010). Critical review: cellular mechanobiology and amoeboid migration. INTEGRATIVE BIOLOGY, 2(11-12), 575-583. doi:10.1039/c0ib00050g.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-B3E6-E Version Permalink: https://hdl.handle.net/21.11116/0000-0004-B3E7-D
Genre: Journal Article

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 Creators:
Guck, Jochen1, Author           
Lautenschlaeger, Franziska2, Author
Paschke, Stephan2, Author
Beil, Michael2, Author
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1External Organizations, ou_persistent22              
2external, ou_persistent22              

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 Abstract: Cell motility is important for tissue homeostasis and plays a central role in various pathologies, notably inflammation and cancer. Research into the critical processes involved in cell migration has so far mostly focused on cell adhesion and proteolytic degradation of the extracellular matrix. However, pharmacological interference with these processes only partially blocks cell motility in vivo. In this review we summarize the arising evidence that the mechanical properties of the cell body have a major role to play in cell motility-especially in a low-adhesion, amoeboid-like migration mode in three-dimensional tissue structures. We summarize the processes determining cell mechanics and discuss relevant measurement technologies including their applications in medical cell biology.

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Language(s): eng - English
 Dates: 2010
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1039/c0ib00050g
 Degree: -

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Title: INTEGRATIVE BIOLOGY
Source Genre: Journal
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Publ. Info: THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND : ROYAL SOC CHEMISTRY
Pages: - Volume / Issue: 2 (11-12) Sequence Number: - Start / End Page: 575 - 583 Identifier: ISSN: 1757-9694