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  Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium

Kong, X., Mathias, S. R., Guadalupe, T. M., Abé, C., Agartz, I. A., Akudjedu, T. N., et al. (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium. Proceedings of the National Academy of Sciences of the United States of America, 115(22), E5154-E5163. doi:10.1073/pnas.1718418115.

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 Creators:
Kong, Xiangzhen1, Author
Mathias, Samuel R.1, Author
Guadalupe, Tulio M.1, Author
Abé, Christoph1, Author
Agartz, Ingrid A.1, Author
Akudjedu, Theophilus N.1, Author
Aleman, André1, Author
Alhusaini, Saud1, Author
Allen, Nicholas B.1, Author
Ames, David J.1, Author
Andreassen, Ole Andreas1, Author
Väsquez, Alejandro Arias1, Author
Armstrong, Nicola J.1, Author
Bergo, Felipe Paulo Guazzi1, Author
Bastin, Mark E.1, Author
Batalla, Albert1, Author
Bauer, Jochen1, Author
Baune, Bernhard T.1, Author
Baur-Streubel, Ramona1, Author
Biederman, Joseph B.1, Author
Blaine, Sara K.1, AuthorBoedhoe, Premika S.W.1, AuthorBøen, Erlend1, AuthorBose, Anushree1, AuthorBralten, Janita B.1, AuthorBrandeis, Daniel1, AuthorBrem, Silvia1, AuthorBrodaty, Henry1, AuthorYüksel, Dilara1, AuthorBrooks, Samantha Jane1, AuthorBuitelaar, Jan K.1, AuthorBürger, Christian1, AuthorBülow, Robin1, AuthorCalhoun, Vince D.1, AuthorCalvo, Anna1, AuthorCanales-Rodríguez, Erick Jorge1, AuthorCañivé, José M.1, AuthorCannon, Dara M.1, AuthorCaparelli, Elisabeth De C.1, AuthorCastellanos, Francisco Xavier1, AuthorCavalleri, Gianpiero L.1, AuthorCendes, Fernando1, AuthorChaim-Avancini, Tiffany Moukbel1, AuthorChantiluke, Kaylita C.1, AuthorChen, Qunlin1, AuthorChen, Xiayu1, AuthorCheng, Yuqi1, AuthorChristakou, Anastasia1, AuthorClark, Vincent P.1, AuthorCoghill, D. R.1, AuthorConnolly, Colm G.1, AuthorConzelmann, Annette1, AuthorCórdova-Palomera, Aldo1, AuthorCousijn, Janna1, AuthorCrow, Timothy John1, AuthorCubillo, Ana1, AuthorDale, Anders M.1, AuthorDannlowski, Udo1, Authorde Bruttopilo, Sara Ambrosino1, Authorde Zeeuw, Patrick1, AuthorDeary, Ian J.1, AuthorDelanty, Norman1, AuthorDemeter, Damion V.1, AuthorDi Martino, Adriana1, AuthorDickie, Erin W.1, AuthorDietsche, Bruno1, AuthorDoan, Nhat Trung1, AuthorDoherty, Colin P.1, AuthorDoyle, Alysa E.1, AuthorDurston, Sarah1, AuthorEarl, Eric A.1, AuthorEhrlich, Stefan1, AuthorEkman, Carl Johan1, AuthorElvsåshagen, Torbjørn1, AuthorEpstein, Jeffery N.1, AuthorFair, Damien A.1, AuthorFaraone, Stephen V.1, AuthorFernández, Guillén1, AuthorFilho, Geraldo Busatto1, AuthorFörster, Katharina1, AuthorFouché, Jean Paul1, AuthorFoxe, John John1, AuthorFrodl, Thomas1, AuthorFuentes-Claramonte, Paola1, AuthorFullerton, Janice M.1, AuthorGarcia, Danielle Do Santos1, AuthorGaravan, Hugh1, AuthorGotlib, Ian H.1, AuthorGoudriaan, Anna Emma1, AuthorGrabe, Hans Jörgen1, AuthorGroenewold, Nynke A.1, AuthorGrotegerd, Dominik1, AuthorGruber, Oliver1, AuthorGurholt, Tiril P.G.1, AuthorHaavik, Jan1, AuthorHahn, Tim1, AuthorHansell, Narelle K.1, AuthorHarris, Mathew A.1, AuthorHartman, Catharina A.1, AuthorHernández, María Del Carmen Valdés1, AuthorHeslenfeld, Dirk J.1, AuthorHester, Robert1, AuthorHibar, Derrek Paul1, AuthorHo, Beng Choon1, AuthorHo, Tiffany C.1, AuthorHoekstra, Pieter J.1, Authorvan Holst, Ruth Janke1, AuthorHoogman, Martine1, AuthorHøvik, Marie Farstad1, AuthorHowells, Fleur Margaret1, AuthorHugdahl, Kenneth1, AuthorHuyser, Chaim1, AuthorIngvar, Martin C.1, AuthorIrwin, Lourdes1, AuthorIshikawa, Akari1, AuthorJames, Anthony C.1, AuthorJahanshad, Neda1, AuthorJernigan, Terry L.1, AuthorJönsson, Erik Gunnar1, AuthorKähler, Claas1, AuthorKaleda, V. G.1, AuthorKelly, Clare1, AuthorKerich, Michael J.1, AuthorKeshavan, Matcheri S.1, AuthorKhadka, Sabin1, AuthorKircher, Tilo1, AuthorKohls, Gregor1, AuthorKonrad, Kerstin1, AuthorKorucuoglu, Ozlem1, AuthorKrämer, Bernd Alexander1, AuthorKrug, Axel1, AuthorKwon, Junsoo1, AuthorLambregts-Rommelse, Nanda N.J., Nanda N.J.1, AuthorLandén, Mikael1, AuthorLázaro, Luisa1, AuthorLebedeva, Irina S.1, AuthorLenroot, Rhoshel1, AuthorLesch, Klaus Peter1, AuthorLi, Qinqin1, AuthorLim, Kelvin O.1, AuthorLiu, Jia1, AuthorLochner, Christine1, AuthorLondon, Edythe D.1, AuthorLonning, Vera1, AuthorLorenzetti, Valentina1, AuthorLuciano, Michelle1, AuthorLuijten, Maartje1, AuthorLundervold, Astri Johansen1, AuthorMacKey, Scott1, AuthorMacMaster, Frank P.1, AuthorMaingault, Sophie1, AuthorMalpas, Charles B.1, AuthorMalt, Ulrik Fredrik1, AuthorMataix-Cols, David1, AuthorMartín-Santos, Roció1, AuthorMayer, Andrew R.1, AuthorMcCarthy, Hazel1, AuthorMitchell, Philip B.1, AuthorMueller, Bryon A.1, AuthorMañiega, Susana Muñoz1, AuthorMazoyer, Bernard M.1, AuthorMcDonald, Colm1, AuthorMcLellan, Quinn1, AuthorMcMahon, Katie L.1, AuthorMcPhilemy, Genevieve1, AuthorMomenan, Reza1, AuthorMorales, Angelica M.1, AuthorNarayanaswamy, Janardhanan C.1, AuthorMoreira, José Carlos Vasques1, AuthorNerland, Stener1, AuthorNestor, Liam J.1, AuthorNewman, Erik1, AuthorNigg, Joel T.1, AuthorNordvik, Jan Egil1, AuthorNovotny, Stephanie E.1, AuthorWeiss, Eileen Oberwelland1, AuthorO'Gorman Tuura, Ruth1, AuthorOosterlaan, Jaap1, AuthorOranje, Bob1, AuthorOrr, Catherine A.1, AuthorOvers, Bronwyn J.1, AuthorPauli, Paul1, AuthorPaulus, Martin P.1, AuthorPlessen, Kerstin Jessica1, Authorvon Polier, Georg G.1, AuthorPomarol-Clotet, Edith1, AuthorPortella Moll, Maria J.1, AuthorQiu, Jiang1, AuthorRadua, Joaquim1, AuthorRamos-Quiroga, Josep Antoni1, AuthorReddy, Yemmigannur Chandrashekhar Janardhan1, AuthorReif, Andreas1, AuthorRoberts, Gloria M.P.1, AuthorRosa, Pedro Gomes P.1, AuthorRubia, Katya1, AuthorSacchet, Matthew D.1, AuthorSachdev, Perminder S.1, AuthorSalvador, Raymond1, AuthorSchmaal, Lianne1, AuthorSchulte-Rüther, Martin1, AuthorSchweren, Lizanne J.S.1, AuthorSeidman, Larry J.1, AuthorSeitz, Jochen1, AuthorSerpa, Mauricio H.1, AuthorShaw, Philip W.1, AuthorShumskaya, Elena N.1, AuthorSilk, Timothy J.1, AuthorSimmons, Alan N.1, AuthorSimulionyte, Egle1, AuthorSinha, Rajita1, AuthorSjoerds, Zsuzsika1, 2, Author              Smelror, Runar Elle1, AuthorSoliva, Joan Carlos1, AuthorSolowij, Nadia1, AuthorDuran, Fabio Luis de Souza1, AuthorSponheim, Scott R.1, AuthorStein, Dan J.1, AuthorStein, Elliot A.1, AuthorStevens, Michael C.1, AuthorStrike, Lachlan T.1, AuthorSudre, Gustavo P.1, AuthorSui, Jing1, AuthorTamm, Leanne1, AuthorTemmingh, Henk S.1, AuthorThoma, Robert J.1, AuthorTomyshev, Alexander S.1, AuthorTronchin, Giulia1, AuthorTurner, Jessica A.1, AuthorUhlmann, Anne1, Authorvan Erp, Theo G.M.1, AuthorVan Den Heuvel, Odile A.1, Authorvan der Meer, Dennis1, Authorvan Eijk, Liza1, AuthorVance, Alasdair L.A.1, AuthorVeer, Ilya Milos1, AuthorVeltman, Dick J.1, AuthorVenkatasubramanian Ganesan, Ganesan1, AuthorVilarroya, Óscar1, AuthorVives-Gilabert, Yolanda1, AuthorVoineskos, Aristotle N.1, AuthorVölzke, Henry1, AuthorVuletic, Daniella1, AuthorWalitza, Susanne1, AuthorWalter, Henrik1, AuthorWalton, Esther1, AuthorWardlaw, Joanna Marguerite M.1, AuthorWen, Wei1, AuthorWestlye, Lars T.1, AuthorWhelan, Christopher D.1, AuthorWhite, Tonya J. H.1, AuthorWiers, Reinout W.H.J.1, AuthorWright, Margaret J.1, AuthorWittfeld, Katharina1, AuthorYang, Tony T.1, AuthorYasuda, Clarissa Lin1, AuthorYoncheva, Yuliya N.1, AuthorYücel, Murat1, AuthorYun, Je-yeon1, AuthorZanetti, Marcus Vinicius1, AuthorZhen, Zonglei1, AuthorZhu, Xingxing1, AuthorZiegler, Georg C.1, AuthorZierhut, Kathrin C.1, Authorde Zubicaray, Greig I.1, AuthorZwiers, Marcel P.1, AuthorGlahn, David C.1, AuthorFranke, Barbara1, AuthorCrivello, Fabrice1, AuthorTzourio-Mazoyer, Nathalie G.1, AuthorFisher, Simon E.1, AuthorThompson, Paul Murray1, AuthorFrancks, Clyde1, AuthorFarde, Lars1, AuthorFlyckt, Lena1, AuthorEngberg, Göran1, AuthorErhardt, Sophie1, AuthorFatouros-Bergman, Helena1, AuthorČervenka, Simon1, AuthorSchwieler, Lilly1, AuthorPiehl, Fredrik1, AuthorCollste, Karin1, AuthorVictorsson, Pauliina1, AuthorMalmqvist, Anna1, AuthorHedberg, Mikael1, AuthorOrhan, Funda1, Author more..
Affiliations:
1External Organizations, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Brain asymmetry; Cortical thickness; Lateralization; Meta-analysis; Surface area
 Abstract: Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (n = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders.

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Language(s): eng - English
 Dates: 2017-10-292018-05-152018-05-29
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1073/pnas.1718418115
PMC: PMC5984496
PMID: 29764998
Other: Epup 2018
 Degree: -

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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 115 (22) Sequence Number: - Start / End Page: E5154 - E5163 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230