English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Investigating genetic links between grapheme-colour synaesthesia and neuropsychiatric traits

Tilot, A. K., Vino, A., Kucera, K. S., Carmichael, D. A., Van den Heuvel, L., Den Hoed, J., et al. (2019). Investigating genetic links between grapheme-colour synaesthesia and neuropsychiatric traits. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences. Advance online publication. doi:10.1098/rstb.2019.0026.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0004-E20E-E Version Permalink: http://hdl.handle.net/21.11116/0000-0004-E3BF-5
Genre: Journal Article

Files

show Files
hide Files
:
tilot_etal_2019_Investigating genetic links ....pdf (Publisher version), 584KB
 
File Permalink:
-
Name:
tilot_etal_2019_Investigating genetic links ....pdf
Description:
-
Visibility:
Private
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Tilot, Amanda K.1, 2, Author              
Vino, Arianna1, Author              
Kucera, Katerina S.1, Author              
Carmichael, Duncan A.3, Author
Van den Heuvel, Loes1, Author
Den Hoed, Joery1, 4, Author              
Sidoroff-Dorso, Anton V.5, Author
Campbell, Archie6, Author
Porteous, David J.6, Author
St Pourcain, Beate1, 7, Author              
Van Leeuwen, Tessa M.8, Author
Ward, Jamie9, Author
Rouw, Romke10, Author
Simner, Julia9, Author
Fisher, Simon E.1, 8, Author              
Affiliations:
1Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
2Keck School of Medicine of University of Southern California, Los Angeles, CA, USA, ou_persistent22              
3Edinburgh Napier University, Edinburgh, UK, ou_persistent22              
4International Max Planck Research School for Language Sciences, MPI for Psycholinguistics, Max Planck Society, Nijmegen, NL, ou_1119545              
5Moscow Pedagogical State University, Moscow, Russia, ou_persistent22              
6University of Edinburgh, Edinburgh, UK, ou_persistent22              
7Population genetics of human communication, MPI for Psycholinguistics, Max Planck Society, ou_2579694              
8Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              
9University of Sussex, Brighton, UK, ou_persistent22              
10University of Amsterdam, Amsterdam, The Netherlands, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Synaesthesia is a neurological phenomenon affecting perception, where triggering stimuli (e.g. letters and numbers) elicit unusual secondary sensory experiences (e.g. colours). Family-based studies point to a role for genetic factors in the development of this trait. However, the contributions of common genomic variation to synaesthesia have not yet been investigated. Here, we present the SynGenes cohort, the largest genotyped collection of unrelated people with grapheme–colour synaesthesia (n = 723). Synaesthesia has been associated with a range of other neuropsychological traits, including enhanced memory and mental imagery, as well as greater sensory sensitivity. Motivated by the prior literature on putative trait overlaps, we investigated polygenic scores derived from published genome-wide scans of schizophrenia and autism spectrum disorder (ASD), comparing our SynGenes cohort to 2181 non-synaesthetic controls. We found a very slight association between schizophrenia polygenic scores and synaesthesia (Nagelkerke's R2 = 0.0047, empirical p = 0.0027) and no significant association for scores related to ASD (Nagelkerke's R2 = 0.00092, empirical p = 0.54) or body mass index (R2 = 0.00058, empirical p = 0.60), included as a negative control. As sample sizes for studying common genomic variation continue to increase, genetic investigations of the kind reported here may yield novel insights into the shared biology between synaesthesia and other traits, to complement findings from neuropsychology and brain imaging.

Details

show
hide
Language(s): eng - English
 Dates: 20192019-10-21
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1098/rstb.2019.0026
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences. Advance online publication
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Royal Society
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0962-8436
CoNE: https://pure.mpg.de/cone/journals/resource/963017382021_1