Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Dopaminergic drug effects on probability weighting during risky decision making

Ojala, K. E., Janssen, L., Hashemi, M. M., Timmer, M. H. M., Geurts, D. E. M., ter Huurne, N. P., et al. (2018). Dopaminergic drug effects on probability weighting during risky decision making. eNeuro, 5(2): e0330-18.2018. doi:10.1523/ENEURO.0330-18.2018.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
Ojala_2018.pdf (Verlagsversion), 504KB
Name:
Ojala_2018.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Ojala, Karita E.1, Autor
Janssen, Lieneke1, Autor           
Hashemi, Mahur Melina1, Autor
Timmer, Monique Harmina Maria1, 2, Autor
Geurts, Dirk Everdina Maria1, 3, Autor
ter Huurne, Niels Peter1, 4, Autor
Cools, Roshan1, 3, Autor
Sescousse, Guillaume1, Autor
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
2Department of Neurology, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
3Department of Psychiatry, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
4Karakter Child and Adolescent Psychiatry University Centre, Radboud University Medical Center, Nijmegen, the Netherlands, ou_persistent22              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Dopamine; Pathological gambling; Probability weighting; Prospect theory; Reward; Risky decision making
 Zusammenfassung: Dopamine has been associated with risky decision-making, as well as with pathological gambling, a behavioral addiction characterized by excessive risk-taking behavior. However, the specific mechanisms through which dopamine might act to foster risk-taking and pathological gambling remain elusive. Here we test the hypothesis that this might be achieved, in part, via modulation of subjective probability weighting during decision making. Human healthy controls (n = 21) and pathological gamblers (n = 16) played a decision-making task involving choices between sure monetary options and risky gambles both in the gain and loss domains. Each participant played the task twice, either under placebo or the dopamine D2/D3 receptor antagonist sulpiride, in a double-blind counterbalanced design. A prospect theory modelling approach was used to estimate subjective probability weighting and sensitivity to monetary outcomes. Consistent with prospect theory, we found that participants presented a distortion in the subjective weighting of probabilities, i.e., they overweighted low probabilities and underweighted moderate to high probabilities, both in the gain and loss domains. Compared with placebo, sulpiride attenuated this distortion in the gain domain. Across drugs, the groups did not differ in their probability weighting, although gamblers consistently underweighted losing probabilities in the placebo condition. Overall, our results reveal that dopamine D2/D3 receptor antagonism modulates the subjective weighting of probabilities in the gain domain, in the direction of more objective, economically rational decision making.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2017-09-222018-02-262018-03-16
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1523/ENEURO.0330-18.2018
PMC: PMC5889481
PMID: 29632870
Anderer: eCollection 2018
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden: ausblenden:
Projektname : -
Grant ID : -
Förderprogramm : Veni Grant
Förderorganisation : Netherlands Organisation for Scientific Research (NWO)

Quelle 1

einblenden:
ausblenden:
Titel: eNeuro
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Washington, DC : Society for Neuroscience
Seiten: - Band / Heft: 5 (2) Artikelnummer: e0330-18.2018 Start- / Endseite: - Identifikator: CoNE: https://pure.mpg.de/cone/journals/resource/106249492X