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  Dopaminergic drug effects on probability weighting during risky decision making

Ojala, K. E., Janssen, L., Hashemi, M. M., Timmer, M. H. M., Geurts, D. E. M., ter Huurne, N. P., et al. (2018). Dopaminergic drug effects on probability weighting during risky decision making. eNeuro, 5(2): e0330-18.2018. doi:10.1523/ENEURO.0330-18.2018.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-ACFC-F Version Permalink: http://hdl.handle.net/21.11116/0000-0004-DC5D-D
Genre: Journal Article

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 Creators:
Ojala, Karita E.1, Author
Janssen, Lieneke1, Author              
Hashemi, Mahur Melina1, Author
Timmer, Monique Harmina Maria1, 2, Author
Geurts, Dirk Everdina Maria1, 3, Author
ter Huurne, Niels Peter1, 4, Author
Cools, Roshan1, 3, Author
Sescousse, Guillaume1, Author
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
2Department of Neurology, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
3Department of Psychiatry, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
4Karakter Child and Adolescent Psychiatry University Centre, Radboud University Medical Center, Nijmegen, the Netherlands, ou_persistent22              

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Free keywords: Dopamine; Pathological gambling; Probability weighting; Prospect theory; Reward; Risky decision making
 Abstract: Dopamine has been associated with risky decision-making, as well as with pathological gambling, a behavioral addiction characterized by excessive risk-taking behavior. However, the specific mechanisms through which dopamine might act to foster risk-taking and pathological gambling remain elusive. Here we test the hypothesis that this might be achieved, in part, via modulation of subjective probability weighting during decision making. Human healthy controls (n = 21) and pathological gamblers (n = 16) played a decision-making task involving choices between sure monetary options and risky gambles both in the gain and loss domains. Each participant played the task twice, either under placebo or the dopamine D2/D3 receptor antagonist sulpiride, in a double-blind counterbalanced design. A prospect theory modelling approach was used to estimate subjective probability weighting and sensitivity to monetary outcomes. Consistent with prospect theory, we found that participants presented a distortion in the subjective weighting of probabilities, i.e., they overweighted low probabilities and underweighted moderate to high probabilities, both in the gain and loss domains. Compared with placebo, sulpiride attenuated this distortion in the gain domain. Across drugs, the groups did not differ in their probability weighting, although gamblers consistently underweighted losing probabilities in the placebo condition. Overall, our results reveal that dopamine D2/D3 receptor antagonism modulates the subjective weighting of probabilities in the gain domain, in the direction of more objective, economically rational decision making.

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Language(s): eng - English
 Dates: 2017-09-222018-02-262018-03-16
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1523/ENEURO.0330-18.2018
PMC: PMC5889481
PMID: 29632870
Other: eCollection 2018
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Project name : -
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Funding program : Veni Grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)

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Title: eNeuro
Source Genre: Journal
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Publ. Info: Washington, DC : Society for Neuroscience
Pages: - Volume / Issue: 5 (2) Sequence Number: e0330-18.2018 Start / End Page: - Identifier: CoNE: https://pure.mpg.de/cone/journals/resource/106249492X