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  Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder

Demirtaş, M., Tornador, C., Falcon, C., Lõpez-Solà, M., Hernández-ribas, R., Pújol, J., et al. (2016). Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder. Human Brain Mapping, 37(8), 2918-2930. doi:10.1002/hbm.23215.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0004-B4C4-3 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0005-6289-2
Genre: Zeitschriftenartikel

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Demirtaş, Murat1, Autor
Tornador, Cristian1, Autor
Falcon, Carles2, 3, Autor
Lõpez-Solà, Marina4, 5, Autor
Hernández-ribas, Rosa6, 7, Autor
Pújol, Jesús8, Autor
Menchón, Jose M.6, 7, 9, Autor
Ritter, Petra10, 11, Autor           
Cardoner, N.12, 13, Autor
Soriano-Mas, Carles6, 7, 14, Autor
Deco, Gustavo1, 15, Autor           
Affiliations:
1Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2BarcelonaBeta Brain Research Center, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain, ou_persistent22              
4Department of Psychology and Neuroscience, University of Colorado Boulder, CO, USA, ou_persistent22              
5MRI Research Unit, CRC Mar, Hospital del Mar, Barcelona, Spain, ou_persistent22              
6Centro de Investigación en Red de Salud Mental (CIBERSAM), Sant Boi de Llobregat, Spain, ou_persistent22              
7Psychiatry Department, Bellvitge Biomedical Research Institute (IDIBELL), Llobregat, Spain, ou_persistent22              
8Department of Radiology, MRI Research Unit, Hospital del Mar, Barcelona, Spain, ou_persistent22              
9Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Spain, ou_persistent22              
10Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
11Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
12Mental Health Department, Depression and Anxiety Program, Parc Taulí Sabadell, Barcelona, Spain, ou_persistent22              
13Department of Psychiatry and Legal Medicine, Universitat Autònoma De Barcelona, Spain, ou_persistent22              
14Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma De Barcelona, Spain, ou_persistent22              
15Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain, ou_persistent22              

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Schlagwörter: Dynamic functional connectivity; fMRI; Major depressive disorder; Mood disorders; Resting state
 Zusammenfassung: Resting-state fMRI (RS-fMRI) has become a useful tool to investigate the connectivity structure of mental health disorders. In the case of major depressive disorder (MDD), recent studies regarding the RS-fMRI have found abnormal connectivity in several regions of the brain, particularly in the default mode network (DMN). Thus, the relevance of the DMN to self-referential thoughts and ruminations has made the use of the resting-state approach particularly important for MDD. The majority of such research has relied on the grand averaged functional connectivity measures based on the temporal correlations between the BOLD time series of various brain regions. We, in our study, investigated the variations in the functional connectivity over time at global and local level using RS-fMRI BOLD time series of 27 MDD patients and 27 healthy control subjects. We found that global synchronization and temporal stability were significantly increased in the MDD patients. Furthermore, the participants with MDD showed significantly increased overall average (static) functional connectivity (sFC) but decreased variability of functional connectivity (vFC) within specific networks. Static FC increased to predominance among the regions pertaining to the default mode network (DMN), while the decreased variability of FC was observed in the connections between the DMN and the frontoparietal network.

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Sprache(n): eng - English
 Datum: 2016-03-142015-07-082016-04-052016-04-282016-08
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/hbm.23215
PMID: 27120982
PMC: PMC5074271
Anderer: Epub 2016
 Art des Abschluß: -

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Projektinformation

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Projektname : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : PSI2013-42091-P
Förderprogramm : Research Personnel Training program
Förderorganisation : Spanish Ministry of Economy and Competitiveness
Projektname : The Human Brain Project / HBP
Grant ID : 604102
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : CP10/00604
Förderprogramm : -
Förderorganisation : del Carlos III Health Institute

Quelle 1

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Titel: Human Brain Mapping
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York : Wiley-Liss
Seiten: - Band / Heft: 37 (8) Artikelnummer: - Start- / Endseite: 2918 - 2930 Identifikator: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686