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  Modulation of tonotopic ventral medial geniculate body is behaviorally relevant for speech recognition

Mihai, P. G., Moerel, M., de Martino, F., Trampel, R., Kiebel, S., & von Kriegstein, K. (2019). Modulation of tonotopic ventral medial geniculate body is behaviorally relevant for speech recognition. eLife, 8: e44837. doi:10.7554/eLife.44837.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-AF0C-B Version Permalink: https://hdl.handle.net/21.11116/0000-0004-DC92-F
Genre: Journal Article

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 Creators:
Mihai, Paul Glad1, 2, Author           
Moerel, Michelle3, 4, 5, Author
de Martino, Federico3, 4, 6, Author
Trampel, Robert7, Author           
Kiebel, Stefan2, Author
von Kriegstein, Katharina1, 2, Author           
Affiliations:
1Max Planck Research Group Neural Mechanisms of Human Communication, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634556              
2Chair of Cognitive and Clinical Neuroscience, Faculty of Psychology, TU Dresden, Germany, ou_persistent22              
3Department of Cognitive Neuroscience, Maastricht University, the Netherlands, ou_persistent22              
4Maastricht Brain Imaging Centre, Maastricht University, the Netherlands, ou_persistent22              
5Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, the Netherlands, ou_persistent22              
6Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA, ou_persistent22              
7Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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 Abstract: Sensory thalami are central sensory pathway stations for information processing. Their role for human cognition and perception, however, remains unclear. Recent evidence suggests an involvement of the sensory thalami in speech recognition. In particular, the auditory thalamus (medial geniculate body, MGB) response is modulated by speech recognition tasks and the amount of this task-dependent modulation is associated with speech recognition abilities. Here, we tested the specific hypothesis that this behaviorally relevant modulation is present in the MGB subsection that corresponds to the primary auditory pathway (i.e., the ventral MGB [vMGB]). We used ultra-high field 7T fMRI to identify the vMGB, and found a significant positive correlation between the amount of task-dependent modulation and the speech recognition performance across participants within left vMGB, but not within the other MGB subsections. These results imply that modulation of thalamic driving input to the auditory cortex facilitates speech recognition.

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Language(s): eng - English
 Dates: 2019-01-092019-07-192019-08-27
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.7554/eLife.44837
PMID: 31453811
PMC: PMC6711666
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Project name : -
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Funding organization : Max Planck Society
Project name : The tiny and the fast: the role of subcortical sensory structures in human communication / SENSOCOM
Grant ID : 647051
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : 864-13-012
Funding program : VIDI Grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : 451-15-012
Funding program : VENI Grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 8 Sequence Number: e44837 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X