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  HH-suite3 for fast remote homology detection and deep protein annotation.

Steinegger, M., Meier, M., Mirdita, M., Vöhringer, H., Haunsberger, S. J., & Söding, J. (2019). HH-suite3 for fast remote homology detection and deep protein annotation. BMC Bioinformatics, 20(1): 473. doi:10.1186/s12859-019-3019-7.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-AF75-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-AF78-1
Genre: Journal Article

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 Creators:
Steinegger, M.1, Author              
Meier, M.1, Author              
Mirdita, M.1, Author              
Vöhringer, H., Author
Haunsberger, S. J., Author
Söding, J.1, Author              
Affiliations:
1Research Group of Computational Biology, MPI for Biophysical Chemistry, Max Planck Society, ou_1933286              

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Free keywords: Algorithm; Functional annotation; Homology detection; Profile HMM; Protein alignment; SIMD; Sequence search
 Abstract: BACKGROUND: HH-suite is a widely used open source software suite for sensitive sequence similarity searches and protein fold recognition. It is based on pairwise alignment of profile Hidden Markov models (HMMs), which represent multiple sequence alignments of homologous proteins. RESULTS: We developed a single-instruction multiple-data (SIMD) vectorized implementation of the Viterbi algorithm for profile HMM alignment and introduced various other speed-ups. These accelerated the search methods HHsearch by a factor 4 and HHblits by a factor 2 over the previous version 2.0.16. HHblits3 is ∼10× faster than PSI-BLAST and ∼20× faster than HMMER3. Jobs to perform HHsearch and HHblits searches with many query profile HMMs can be parallelized over cores and over cluster servers using OpenMP and message passing interface (MPI). The free, open-source, GPLv3-licensed software is available at https://github.com/soedinglab/hh-suite . CONCLUSION: The added functionalities and increased speed of HHsearch and HHblits should facilitate their use in large-scale protein structure and function prediction, e.g. in metagenomics and genomics projects.

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Language(s): eng - English
 Dates: 2019-09-14
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1186/s12859-019-3019-7
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Title: BMC Bioinformatics
Source Genre: Journal
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Pages: 15 Volume / Issue: 20 (1) Sequence Number: 473 Start / End Page: - Identifier: -