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  Adiposity related brain plasticity induced by bariatric surgery

Rullmann, M., Preusser, S., Poppitz, S., Heba, S., Gousias, K., Hoyer, J., et al. (2019). Adiposity related brain plasticity induced by bariatric surgery. Frontiers in Human Neuroscience, 13: 290. doi:10.3389/fnhum.2019.00290.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-AF95-F Version Permalink: http://hdl.handle.net/21.11116/0000-0004-DC94-D
Genre: Journal Article

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 Creators:
Rullmann, Michael1, 2, 3, 4, Author              
Preusser, Sven3, Author
Poppitz, Sindy1, 3, Author
Heba, Stefanie5, Author
Gousias, Konstantinos6, Author
Hoyer, Jana7, 8, Author
Schütz, Tatjana1, Author
Dietrich, Arne1, 9, Author
Mueller, Karsten10, Author              
Hankir, Mohammed K.11, Author
Pleger, Burkhard1, 3, 4, 5, Author              
Affiliations:
1Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
2Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
5Department of Neurology, University Hospital Bergmannsheil, Bochum, Germany, ou_persistent22              
6Department of Neurosurgery, University Hospital Bergmannsheil, Bochum, Germany, ou_persistent22              
7Department of Behavioral Epidemiology, TU Dresden, Germany, ou_persistent22              
8Faculty of Psychology, TU Dresden, Germany, ou_persistent22              
9Department of Bariatric Surgery, University Hospital Leipzig, Germany, ou_persistent22              
10Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
11Department of Surgery, University Hospital Würzburg, Germany, ou_persistent22              

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Free keywords: Adiposity; Magnetic resonance imaging; Brain plasticity; Bariatric surgery; Gastric-bypass surgery
 Abstract: Previous magnetic resonance imaging (MRI) studies revealed structural-functional brain reorganization 12 months after gastric-bypass surgery, encompassing cortical and subcortical regions of all brain lobes as well as the cerebellum. Changes in the mean of cluster-wise gray/white matter density (GMD/WMD) were correlated with the individual loss of body mass index (BMI), rendering the BMI a potential marker of widespread surgery-induced brain plasticity. Here, we investigated voxel-by-voxel associations between surgery-induced changes in adiposity, metabolism and inflammation and markers of functional and structural neural plasticity. We re-visited the data of patients who underwent functional and structural MRI, 6 months (n = 27) and 12 months after surgery (n = 22), and computed voxel-wise regression analyses. Only the surgery-induced weight loss was significantly associated with brain plasticity, and this only for GMD changes. After 6 months, weight loss overlapped with altered GMD in the hypothalamus, the brain’s homeostatic control site, the lateral orbitofrontal cortex, assumed to host reward and gustatory processes, as well as abdominal representations in somatosensory cortex. After 12 months, weight loss scaled with GMD changes in right cerebellar lobule VII, involved in language-related/cognitive processes, and, by trend, with the striatum, assumed to underpin (food) reward. These findings suggest time-dependent and weight-loss related gray matter plasticity in brain regions involved in the control of eating, sensory processing and cognitive functioning.

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Language(s): eng - English
 Dates: 2019-04-082019-08-122019-08-27
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnhum.2019.00290
PMID: 31507395
PMC: PMC6718731
Other: eCollection 2019
 Degree: -

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Project name : -
Grant ID : 01E01001
Funding program : -
Funding organization : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
Project name : Obesity Mechanisms / SFB 1052
Grant ID : 209933838
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 13 Sequence Number: 290 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5161