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  Melting transitions in biomembranes.

Mužić, T., Tounsi, F., Madsen, S. B., Pollakowski, D., Konrad, M., & Heimburg, T. (2019). Melting transitions in biomembranes. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1861(11): 183026. doi:10.1016/j.bbamem.2019.07.014.

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Mužić, T., Autor
Tounsi, F., Autor
Madsen, S. B., Autor
Pollakowski, D., Autor
Konrad, M.1, Autor           
Heimburg, T., Autor
Affiliations:
1Research Group of Enzyme Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578612              

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Schlagwörter: B. subtilis; E. coli; Elastic constants; Ions; Lung surfactant; Nerves; Thermodynamics
 Zusammenfassung: We investigated melting transitions in native biological membranes containing their membrane proteins. The membranes originated from E. coli, B. subtilis, lung surfactant and nerve tissue from the spinal cord of several mammals. For some preparations, we studied the pressure, pH and ionic strength dependence of the transition. For porcine spine, we compared the transition of the native membrane to that of the extracted lipids. All preparations displayed melting transitions of 10-20° below physiological or growth temperature, independent of the organism of origin and the respective cell type. We found that the position of the transitions in E. coli membranes depends on the growth temperature. We discuss these findings in the context of the thermodynamic theory of membrane fluctuations close to transition that predicts largely altered elastic constants, an increase in fluctuation lifetime and in membrane permeability. We also discuss how to distinguish lipid melting from protein unfolding transitions. Since the feature of a transition slightly below physiological temperature is conserved even when growth conditions change, we conclude that the transitions are likely to be of major biological importance for the survival and the function of the cell.

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Sprache(n): eng - English
 Datum: 2019-08-262019-11-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.bbamem.2019.07.014
 Art des Abschluß: -

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Titel: Biochimica et Biophysica Acta (BBA) - Biomembranes
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: 11 Band / Heft: 1861 (11) Artikelnummer: 183026 Start- / Endseite: - Identifikator: -