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  Chemical and Biocatalytic Routes to Arbutin

Zhou, H., Zhao, J., Li, A., & Reetz, M. T. (2019). Chemical and Biocatalytic Routes to Arbutin. Molecules, 24(18): 3303. doi:10.3390/molecules24183303.

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 Creators:
Zhou, Hangyu1, Author
Zhao, Jing1, Author
Li, Aitao1, Author
Reetz, Manfred T.2, 3, Author           
Affiliations:
1State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan 430062, China, ou_persistent22              
2Research Department Reetz, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445588              
3Chemistry Department, Philipps-University, Hans-Meerwein-Str. 4, 35032 Marburg, Germany, ou_persistent22              

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Free keywords: arbutin; glycosyltransferases; glucosides; shikimate pathway; cosmetics; directed evolution; Chinese folk medicines
 Abstract: Arbutin (also called β-arbutin) is a natural product occurring in the leaves of a variety of different plants, the bearberries of the Ericaceae and Saxifragaceae families being prominent examples. It is a β-glucoside derived from hydroquinone (HQ; 1,4-dihydroxybenzene). Arbutin has been identified in traditional Chinese folk medicines as having, inter alia, anti-microbial, anti-oxidant, and anti-inflammatory properties that useful in the treatment of different ailments including urinary diseases. Today, it is also used worldwide for the treatment of skin ailments by way of depigmenting, which means that arbutin is a component of many products in the cosmetics and healthcare industries. It is also relevant in the food industry. Hundreds of publications have appeared describing the isolation, structure determination, toxicology, synthesis, and biological properties of arbutin as well as the molecular mechanism of melanogenesis (tyrosinase inhibition). This review covers the most important aspects with special emphasis on the chemical and biocatalytic methods for the production of arbutin.

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Language(s): eng - English
 Dates: 2019-08-032019-09-092019-09-11
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3390/molecules24183303
 Degree: -

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Title: Molecules
Source Genre: Journal
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Publ. Info: Basel : MDPI
Pages: - Volume / Issue: 24 (18) Sequence Number: 3303 Start / End Page: - Identifier: ISSN: 1420-3049
CoNE: https://pure.mpg.de/cone/journals/resource/954925623244