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  P-31 magnetic resonance spectroscopy (MRS) to detect abnormalities in energy metabolism of muscle tissue in mitochondrial encephalomyopathies and migraine?

Jauslin, M., Dydak, U., Henning, A., Sprott, H., Boesiger, P., & Sandor, P. (2006). P-31 magnetic resonance spectroscopy (MRS) to detect abnormalities in energy metabolism of muscle tissue in mitochondrial encephalomyopathies and migraine?. Poster presented at 16th Migraine Trust International Symposium, London, UK.

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Jauslin, M, Author
Dydak, U, Author
Henning, A1, Author              
Sprott, H, Author
Boesiger, P, Author
Sandor, PS, Author
Affiliations:
1External Organizations, ou_persistent22              

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 Abstract: Background: Previous studies have shown abnormalities in the recovery rate of the phosphocreatin signal normalized with pH (TPCr/pH) after physical exercise in patients with Mitochondrial Encephalomyopathies (ME) with a well- demonstrated defect in the energy metabolism. Objective: To study the hypothesis of systemic energy failure in migraine by comparing the recovery rate TPCr/pH after physical exercise in healthy volunteers (HV), ME as positive controls and in migraine patients with aura (MA) using a short exercise paradigm. Methods: The calf muscles of 10 ME, 11 MA and 25 HV were examined with 31 P magnetic resonance spectroscopy (MRS). A timeseries of 100 MRS measurements (6 seconds each) was recorded with a surface coil on a 1.5 T Philips Intera MR Scanner: rest (20 spectra) – exercise (20) – recovery (60). The pH values and the recovery rates TPCr/pH were calculated from the postprocessed spectra. A sequence of increasingly rigorous quality criteria was applied to the data. Results and Conclusion: The results of 7 ME, 5 MA and 18 HV fulfilled rigorous quality criteria and were therefore included into analysis. Independently of the level of applied quality criteria, no difference in TPCr/pH after exercise was found between ME and HV. This result is most likely due to the too short and sprintlike exercise paradigm which would not allow the oxidative metabolism to run at its full capacity and therefore is insufficient to yield the MR-detectable abnormalities in mitochondrial function of ME and MA.

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 Dates: 2006-11
 Publication Status: Published in print
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 Identifiers: DOI: 10.1111/j.1468-2982.2006.01241.x
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Title: 16th Migraine Trust International Symposium
Place of Event: London, UK
Start-/End Date: 2006-09-18 - 2006-09-20

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Title: Cephalagia
Source Genre: Journal
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Pages: - Volume / Issue: 26 (11) Sequence Number: PD.18 Start / End Page: 1387 Identifier: ISSN: 0333-1024