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  MRI in traumatic spinal cord injury: From clinical assessment to neuroimaging biomarkers

Freund, P., Seif, M., Weiskopf, N., Friston, K., Fehlings, M. G., Thompson, A. J., et al. (2019). MRI in traumatic spinal cord injury: From clinical assessment to neuroimaging biomarkers. The Lancet Neurology, 18(12), 1123-1135. doi:10.1016/S1474-4422(19)30138-3.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-B67F-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-4CED-C
Genre: Journal Article

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 Creators:
Freund, Patrick1, 2, 3, 4, 5, Author              
Seif, Maryam1, 5, Author
Weiskopf, Nikolaus4, 5, Author              
Friston, Karl4, Author
Fehlings, Michael G.6, Author
Thompson, Alan J.3, Author
Curt, Armin1, Author
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Department of Neurology, University Hospital Zurich, Switzerland, ou_persistent22              
3Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
4Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
5Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              
6Spine Program, Department of Surgery, University of Toronto, ON, Canada, ou_persistent22              

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 Abstract: Traumatic spinal cord injury occurs when an external physical impact damages the spinal cord and leads to permanent neurological dysfunction and disability, and it is associated with a high socioeconomic burden. Conventional MRI plays a crucial role in the diagnostic workup as it reveals extrinsic compression of the spinal cord and disruption of the discoligamentous complex. Additionally, it can reveal macrostructural evidence of primary intramedullary damage such as haemorrhage, oedema, post-traumatic cystic cavities, and tissue bridges. Quantitative MRI, such as magnetisation transfer, magnetic resonance relaxation mapping, and diffusion imaging, enables the tracking of secondary changes across the neuraxis at the microstructural level. Both conventional MRI and quantitative MRI metrics, obtained early after spinal cord injury, are predictive of clinical outcome. Thus, neuroimaging biomarkers could serve as surrogate endpoints for more efficient future trials targeting acute and chronic spinal cord injury. The adoption of neuroimaging biomarkers in centres for spinal cord injury might lead to personalised patient care.

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Language(s): eng - English
 Dates: 2019-08-092019-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/S1474-4422(19)30138-3
PMID: 31405713
PII: S1474-4422(19)30138-3
Other: Epub ahead of print
 Degree: -

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Title: The Lancet Neurology
  Other : Lancet Neurol.
Source Genre: Journal
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Publ. Info: London, UK : Elsevier
Pages: - Volume / Issue: 18 (12) Sequence Number: - Start / End Page: 1123 - 1135 Identifier: ISSN: 1474-4422
CoNE: https://pure.mpg.de/cone/journals/resource/111025286560038