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  MRI in traumatic spinal cord injury: From clinical assessment to neuroimaging biomarkers

Freund, P., Seif, M., Weiskopf, N., Friston, K., Fehlings, M. G., Thompson, A. J., et al. (2019). MRI in traumatic spinal cord injury: From clinical assessment to neuroimaging biomarkers. The Lancet Neurology, 18(12), 1123-1135. doi:10.1016/S1474-4422(19)30138-3.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-B67F-1 Version Permalink: https://hdl.handle.net/21.11116/0000-0006-72FF-B
Genre: Journal Article

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 Creators:
Freund, Patrick1, 2, 3, 4, 5, Author           
Seif, Maryam1, 5, Author
Weiskopf, Nikolaus4, 5, Author           
Friston, Karl4, Author
Fehlings, Michael G.6, Author
Thompson, Alan J.3, Author
Curt, Armin1, Author
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Department of Neurology, University Hospital Zurich, Switzerland, ou_persistent22              
3Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
4Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
5Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              
6Spine Program, Department of Surgery, University of Toronto, ON, Canada, ou_persistent22              

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 Abstract: Traumatic spinal cord injury occurs when an external physical impact damages the spinal cord and leads to permanent neurological dysfunction and disability, and it is associated with a high socioeconomic burden. Conventional MRI plays a crucial role in the diagnostic workup as it reveals extrinsic compression of the spinal cord and disruption of the discoligamentous complex. Additionally, it can reveal macrostructural evidence of primary intramedullary damage such as haemorrhage, oedema, post-traumatic cystic cavities, and tissue bridges. Quantitative MRI, such as magnetisation transfer, magnetic resonance relaxation mapping, and diffusion imaging, enables the tracking of secondary changes across the neuraxis at the microstructural level. Both conventional MRI and quantitative MRI metrics, obtained early after spinal cord injury, are predictive of clinical outcome. Thus, neuroimaging biomarkers could serve as surrogate endpoints for more efficient future trials targeting acute and chronic spinal cord injury. The adoption of neuroimaging biomarkers in centres for spinal cord injury might lead to personalised patient care.

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Language(s): eng - English
 Dates: 2019-08-092019-12
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/S1474-4422(19)30138-3
PMID: 31405713
PII: S1474-4422(19)30138-3
Other: Epub ahead of print
 Degree: -

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Project name : Non-Invasive In-Vivo Histology in Health and Disease Using Magnetic Resonance Imaging (MRI) / HMRI
Grant ID : 616905
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Entschlüsselung der pathophysiologischen Prozesse induziert durch eine Querschnittlähmung: Anwendung von MRT basierter in vivo und ex vivo Histologie / hMRIofSCI
Grant ID : 01EW1711A B
Funding program : ERA-NET Neuron
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : Taking imaging into the therapeutic domain: Self-regulation of brain systems for mental disorders / BRAINTRAIN
Grant ID : 602186
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial / NISCI
Grant ID : 681094
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)
Project name : -
Grant ID : 15.0137
Funding program : -
Funding organization : Swiss State Secretariat for Education, Research and Innovation (SERI)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Siemens Healthcare
Project name : -
Grant ID : -
Funding program : UCL Impact Awards
Funding organization : UCL
Project name : This are just the project information about the MPI for Human Cognitive and Brain Sciences. More information available in the paper.
Grant ID : -
Funding program : -
Funding organization : -

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Title: The Lancet Neurology
  Other : Lancet Neurol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London, UK : Elsevier
Pages: - Volume / Issue: 18 (12) Sequence Number: - Start / End Page: 1123 - 1135 Identifier: ISSN: 1474-4422
CoNE: https://pure.mpg.de/cone/journals/resource/111025286560038