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  A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+dynamics.

Costa, W. S., Van der Auwera, P., Glock, C., Liewald, J. F., Bach, M., Schüler, C., et al. (2019). A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+dynamics. Nature Communications, 10: 4095. doi:10.1038/s41467-019-12098-5.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-B8E6-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-B8F3-A
Genre: Journal Article

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 Creators:
Costa, W. S., Author
Van der Auwera, P., Author
Glock, C., Author
Liewald, J. F., Author
Bach, M., Author
Schüler, C., Author
Wabnig, S., Author
Oranth, A., Author
Masurat, F.1, Author              
Bringmann, H.1, Author              
Schoofs, L., Author
Stelzer, E. H. K., Author
Fischer, S. C., Author
Gottschalk, A., Author
Affiliations:
1Research Group of Sleep and Waking, MPI for biophysical chemistry, Max Planck Society, ou_578607              

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 Abstract: Animals must slow or halt locomotion to integrate sensory inputs or to change direction. In Caenorhabditis elegans, the GABAergic and peptidergic neuron RIS mediates developmentally timed quiescence. Here, we show RIS functions additionally as a locomotion stop neuron. RIS optogenetic stimulation caused acute and persistent inhibition of locomotion and pharyngeal pumping, phenotypes requiring FLP-11 neuropeptides and GABA. RIS photoactivation allows the animal to maintain its body posture by sustaining muscle tone, yet inactivating motor neuron oscillatory activity. During locomotion, RIS axonal Ca2+ signals revealed functional compartmentalization: Activity in the nerve ring process correlated with locomotion stop, while activity in a branch correlated with induced reversals. GABA was required to induce, and FLP-11 neuropeptides were required to sustain locomotion stop. RIS attenuates neuronal activity and inhibits movement, possibly enabling sensory integration and decision making, and exemplifies dual use of one cell across development in a compact nervous system.

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Language(s): eng - English
 Dates: 2019-09-10
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41467-019-12098-5
 Degree: -

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Title: Nature Communications
Source Genre: Journal
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Publ. Info: -
Pages: 15 Volume / Issue: 10 Sequence Number: 4095 Start / End Page: - Identifier: -