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  Model-based myocardial T1 mapping with sparsity constraints using single-shot inversion-recovery radial FLASH cardiovascular magnetic resonance.

Wang, X., Kohler, F., Unterberg-Buchwald, C., Lotz, J., Frahm, J., & Uecker, M. (2019). Model-based myocardial T1 mapping with sparsity constraints using single-shot inversion-recovery radial FLASH cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance, 21: 60. doi:10.1186/s12968-019-0570-3.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-B91E-B Version Permalink: http://hdl.handle.net/21.11116/0000-0004-B925-2
Genre: Journal Article

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 Creators:
Wang, X., Author
Kohler, F., Author
Unterberg-Buchwald, C., Author
Lotz, J., Author
Frahm, J.1, Author              
Uecker, M., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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Free keywords: Model-based reconstruction; Myocardial T1 mapping; Radial FLASH; Sparsity constraint
 Abstract: BACKGROUND: This study develops a model-based myocardial T1 mapping technique with sparsity constraints which employs a single-shot inversion-recovery (IR) radial fast low angle shot (FLASH) cardiovascular magnetic resonance (CMR) acquisition. The method should offer high resolution, accuracy, precision and reproducibility. METHODS: The proposed reconstruction estimates myocardial parameter maps directly from undersampled k-space which is continuously measured by IR radial FLASH with a 4 s breathhold and retrospectively sorted based on a cardiac trigger signal. Joint sparsity constraints are imposed on the parameter maps to further improve T1 precision. Validations involved studies of an experimental phantom and 8 healthy adult subjects. RESULTS: In comparison to an IR spin-echo reference method, phantom experiments with T1 values ranging from 300 to 1500 ms revealed good accuracy and precision at simulated heart rates between 40 and 100 bpm. In vivo T1 maps achieved better precision and qualitatively better preservation of image features for the proposed method than a real-time CMR approach followed by pixelwise fitting. Apart from good inter-observer reproducibility (0.6% of the mean), in vivo results confirmed good intra-subject reproducibility (1.05% of the mean for intra-scan and 1.17, 1.51% of the means for the two inter-scans, respectively) of the proposed method. CONCLUSION: Model-based reconstructions with sparsity constraints allow for single-shot myocardial T1 maps with high spatial resolution, accuracy, precision and reproducibility within a 4 s breathhold. Clinical trials are warranted.

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Language(s): eng - English
 Dates: 2019-09-19
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1186/s12968-019-0570-3
 Degree: -

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Title: Journal of Cardiovascular Magnetic Resonance
Source Genre: Journal
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Publ. Info: -
Pages: 11 Volume / Issue: 21 Sequence Number: 60 Start / End Page: - Identifier: -