English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Lost in translation?: On the need for convergence in animal and human studies on the role of dopamine in diet-induced obesity

Janssen, L., Herzog, N., Waltmann, M., Breuer, N., Wiencke, K., Rausch, F., et al. (2019). Lost in translation?: On the need for convergence in animal and human studies on the role of dopamine in diet-induced obesity. Current Addiction Reports, 6(3), 229-257. doi:10.1007/s40429-019-00268-w.

Item is

Files

show Files
hide Files
:
Janssen_Herzog_2019.pdf (Publisher version), 4MB
Name:
Janssen_Herzog_2019.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Janssen, Lieneke1, 2, Author           
Herzog, Nadine1, 2, Author           
Waltmann, Maria1, 2, Author           
Breuer, Nora1, 2, Author           
Wiencke, Kathleen1, 2, Author           
Rausch, Franziska1, 2, 3, Author           
Hartmann, Hendrik2, 3, Author           
Poessel, Maria2, Author           
Horstmann, Annette1, 2, 3, 4, Author           
Affiliations:
1Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
4Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland, ou_persistent22              

Content

show
hide
Free keywords: Obesity; Dopamine; Diet; Frontostriatal loops
 Abstract: Purpose of Review

Animal and human studies suggest that diet-induced obesity and plasticity in the central dopaminergic system are linked. However, it is unclear whether observed changes depend on diet or obesity, and whether they are specific to brain regions and cognitive functions. Here, we focus on neural and cognitive changes in frontostriatal circuits.
Recent Findings

Both diet and obesity affect dopaminergic transmission. However, site and direction of effects are inconsistent across species and studies. Non-specific changes are observed spanning all frontostriatal loops, from sensory input to motivated behaviour. Given the impact of peripheral signals on central dopaminergic signalling and the interaction between the frontostriatal loops, modulation of dopamine likely propagates through all loops and, thus, affects behaviour on various levels of complexity.
Summary

To improve convergence between animal and human studies on diet-induced obesity, animal studies should include sophisticated cognitive measures and diets resembling human obesogenic diets, and human studies should adopt diet interventions and longitudinal designs.

Details

show
hide
Language(s): eng - English
 Dates: 2019-08-092019-09
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/s40429-019-00268-w
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society
Project name : Obesity Mechanisms / SFB 1052
Grant ID : -
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 01EO1501
Funding program : -
Funding organization : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Roland Ernst Stiftung

Source 1

show
hide
Title: Current Addiction Reports
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cham : Springer International Publishing
Pages: - Volume / Issue: 6 (3) Sequence Number: - Start / End Page: 229 - 257 Identifier: ISSN: 2196-2952
CoNE: https://pure.mpg.de/cone/journals/resource/2196-2952