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  Lost in translation?: On the need for convergence in animal and human studies on the role of dopamine in diet-induced obesity

Janssen, L., Herzog, N., Waltmann, M., Breuer, N., Wiencke, K., Rausch, F., et al. (2019). Lost in translation?: On the need for convergence in animal and human studies on the role of dopamine in diet-induced obesity. Current Addiction Reports, 6(3), 229-257. doi:10.1007/s40429-019-00268-w.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-B9DA-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-E352-F
Genre: Journal Article

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Janssen_Herzog_2019.pdf (Publisher version), 4MB
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 Creators:
Janssen, Lieneke1, 2, Author              
Herzog, Nadine1, 2, Author              
Waltmann, Maria1, 2, Author              
Breuer, Nora1, 2, Author              
Wiencke, Kathleen1, 2, Author              
Rausch, Franziska1, 2, 3, Author              
Hartmann, Hendrik2, 3, Author              
Poessel, Maria2, Author              
Horstmann, Annette1, 2, 3, 4, Author              
Affiliations:
1Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
4Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland, ou_persistent22              

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Free keywords: Obesity; Dopamine; Diet; Frontostriatal loops
 Abstract: Purpose of Review Animal and human studies suggest that diet-induced obesity and plasticity in the central dopaminergic system are linked. However, it is unclear whether observed changes depend on diet or obesity, and whether they are specific to brain regions and cognitive functions. Here, we focus on neural and cognitive changes in frontostriatal circuits. Recent Findings Both diet and obesity affect dopaminergic transmission. However, site and direction of effects are inconsistent across species and studies. Non-specific changes are observed spanning all frontostriatal loops, from sensory input to motivated behaviour. Given the impact of peripheral signals on central dopaminergic signalling and the interaction between the frontostriatal loops, modulation of dopamine likely propagates through all loops and, thus, affects behaviour on various levels of complexity. Summary To improve convergence between animal and human studies on diet-induced obesity, animal studies should include sophisticated cognitive measures and diets resembling human obesogenic diets, and human studies should adopt diet interventions and longitudinal designs.

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Language(s): eng - English
 Dates: 2019-08-092019-09
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s40429-019-00268-w
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Title: Current Addiction Reports
Source Genre: Journal
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Publ. Info: Cham : Springer International Publishing
Pages: - Volume / Issue: 6 (3) Sequence Number: - Start / End Page: 229 - 257 Identifier: ISSN: 2196-2952
CoNE: https://pure.mpg.de/cone/journals/resource/2196-2952