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  Enhanced food-related responses in the ventral medial prefrontal cortex in narcolepsy type 1

van Holst, R. J., Janssen, L., van Mierlo, P., Lammers, G. J., Cools, R., Overeem, S., et al. (2018). Enhanced food-related responses in the ventral medial prefrontal cortex in narcolepsy type 1. Scientific Reports, 8: 16391. doi:10.1038/s41598-018-34647-6.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-BA15-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-E4A8-D
Genre: Journal Article

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 Creators:
van Holst, Ruth Janke 1, 2, 3, Author
Janssen, Lieneke2, Author              
van Mierlo, Petra 4, Author
Lammers, Gert Jan 5, 6, Author
Cools, Roshan2, 7, Author
Overeem, Sebastiaan 4, 8, Author
Aarts, Esther2, Author
Affiliations:
1Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands, ou_persistent22              
2Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands, ou_persistent22              
3Department of Psychiatry, Amsterdam UMC, University of Amsterdam, The Netherlands, ou_persistent22              
4Sleep Medicine Center Kempenhaeghe, Heeze, The Netherlands, ou_persistent22              
5Sleep-Wake Center SEIN, Heemstede, The Netherlands, ou_persistent22              
6Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands, ou_persistent22              
7Department of Psychiatry, Radboud university medical center, Nijmegen, The Netherlands, ou_persistent22              
8Eindhoven University of Technology, The Netherlands, ou_persistent22              

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 Abstract: Narcolepsy type 1 is a chronic sleep disorder caused by a deficiency of the orexin (hypocretin) neuropeptides. In addition to sleep regulation, orexin is important for motivated control processes. Weight gain and obesity are common in narcolepsy. However, the neurocognitive processes associated with food-related control and overeating in narcolepsy are unknown. We explored the neural correlates of general and food-related attentional control in narcolepsy-type-1 patients (n = 23) and healthy BMI-matched controls (n = 20). We measured attentional bias to food words with a Food Stroop task and general executive control with a Classic Stroop task during fMRI. Moreover, using multiple linear regression, we assessed the relative contribution of neural responses during Food Stroop and Classic Stroop to spontaneous snack intake. Relative to healthy controls, narcolepsy patients showed enhanced ventral medial prefrontal cortex responses and connectivity with motor cortex during the Food Stroop task, but attenuated dorsal medial prefrontal cortex responses during the Classic Stroop task. Moreover, the former activity but not the latter, was a significant predictor of spontaneous snack intake. These findings demonstrate that narcolepsy, characterized by orexin deficiency, is associated with decreased dorsal medial prefrontal cortex responses during general executive control and enhanced ventral medial prefrontal cortex responses during food-driven attention.

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Language(s): eng - English
 Dates: 2018-07-092018-10-082018-11-06
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41598-018-34647-6
PMID: 30401926
PMC: PMC6219562
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Project name : -
Grant ID : 016.116.371
Funding program : VIDI Research Grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : 016.135.023
Funding program : VENI Grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 8 Sequence Number: 16391 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322