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  Awakening: Predicting external stimulation to force transitions between different brain states

Deco, G., Cruzat, J., Cabral, J., Tagliazucchi, E., Laufs, H., Logothetis, N. K., & Kringelbach, M. L. (2019). Awakening: Predicting external stimulation to force transitions between different brain states. Proceedings of the National Academy of Sciences of the United States of America, 116(36), 18088-18097. doi:10.1073/pnas.1905534116.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0004-BD09-E 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0005-A355-3
資料種別: 学術論文

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Deco_Cruzat_Cabral_2019.pdf (出版社版), 3MB
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https://hdl.handle.net/21.11116/0000-0005-9E83-5
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Deco_Cruzat_Cabral_2019.pdf
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作成者

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 作成者:
Deco, Gustavo1, 2, 3, 4, 5, 著者           
Cruzat, Josephine1, 2, 著者
Cabral, Joana6, 7, 8, 著者
Tagliazucchi, Enzo9, 10, 著者
Laufs, Helmut10, 11, 著者
Logothetis, Nikos K.12, 13, 著者
Kringelbach, Morten L.6, 7, 8, 著者
所属:
1Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
3Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
4Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
5Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia, ou_persistent22              
6Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
7Department of Clinical Medicine, Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
8ICVS - Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ou_persistent22              
9Institute of Medical Psychology and Medical Sociology, University Hospital of Schleswig-Holstein, Kiel, Germany, ou_persistent22              
10Brain Imaging Centre, Goethe University, Frankfurt, Germany, ou_persistent22              
11Department of Neurology, Christian Albrecht University Kiel, Germany, ou_persistent22              
12Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ou_persistent22              
13Centre for Imaging Sciences, University of Manchester, United Kingdom, ou_persistent22              

内容説明

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キーワード: -
 要旨: A fundamental problem in systems neuroscience is how to force a transition from one brain state to another by external driven stimulation in, for example, wakefulness, sleep, coma, or neuropsychiatric diseases. This requires a quantitative and robust definition of a brain state, which has so far proven elusive. Here, we provide such a definition, which, together with whole-brain modeling, permits the systematic study in silico of how simulated brain stimulation can force transitions between different brain states in humans. Specifically, we use a unique neuroimaging dataset of human sleep to systematically investigate where to stimulate the brain to force an awakening of the human sleeping brain and vice versa. We show where this is possible using a definition of a brain state as an ensemble of “metastable substates,” each with a probabilistic stability and occurrence frequency fitted by a generative whole-brain model, fine-tuned on the basis of the effective connectivity. Given the biophysical limitations of direct electrical stimulation (DES) of microcircuits, this opens exciting possibilities for discovering stimulation targets and selecting connectivity patterns that can ensure propagation of DES-induced neural excitation, potentially making it possible to create awakenings from complex cases of brain injury.

資料詳細

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言語: eng - English
 日付: 2019-04-032019-06-202019-08-192019-09-03
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1073/pnas.1905534116
その他: Epub 2019
PMID: 31427539
PMC: PMC6731634
 学位: -

関連イベント

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Project information

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Project name : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : Human Brain Project Specific Grant Agreement 2 / HBP SGA2
Grant ID : 785907
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : SGR 1545
Funding program : Catalan AGAUR Programme 2017
Funding organization : Generalitat de Catalunya
Project name : -
Grant ID : -
Funding program : -
Funding organization : Portuguese Foundation for Science and Technology
Project name : -
Grant ID : CEECIND/03325/2017
Funding program : -
Funding organization : Portuguese Foundation for Science and Technology
Project name : The plasticity of parental caregiving: characterizing the brain mechanisms underlying normal and disrupted development of parenting / CAREGIVING
Grant ID : 615539
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : DNRF117
Funding program : -
Funding organization : Danish National Research Foundation

出版物 1

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出版物名: Proceedings of the National Academy of Sciences of the United States of America
  その他 : Proc. Acad. Sci. USA
  その他 : Proc. Acad. Sci. U.S.A.
  その他 : Proceedings of the National Academy of Sciences of the USA
  省略形 : PNAS
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: Washington, D.C. : National Academy of Sciences
ページ: - 巻号: 116 (36) 通巻号: - 開始・終了ページ: 18088 - 18097 識別子（ISBN, ISSN, DOIなど）: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230