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  Glutamate in salience network predicts BOLD response in default mode network during salience processing

von Düring, F., Ristow, I., Li, M., Denzel, D., Colic, L., Demenescu, L., et al. (2019). Glutamate in salience network predicts BOLD response in default mode network during salience processing. Frontiers in Behavioral Neuroscience, 13: 232, pp. 1-12. doi:10.3389/fnbeh.2019.00232.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-BD29-A Version Permalink: http://hdl.handle.net/21.11116/0000-0004-CA7F-B
Genre: Journal Article

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von Düring, F, Author
Ristow, I, Author
Li, M1, 2, Author              
Denzel, D, Author
Colic, L, Author
Demenescu, LR, Author
Li, S, Author
Borchardt, V, Author
Liebe, T, Author
Vogel, M, Author
Walter, M1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Background: Brain investigations identified salience network (SN) comprising the dorsal Anterior Cingulate Cortex (dACC) and the Anterior Insula (AI). Magnetic resonance spectroscopy (MRS) studies revealed the link between the glutamate concentration in the ACC and alterations in attentional scope. Hence, we investigated whether glutamate concentration in the dACC modulates brain response during salience processing. Methods: Twenty-seven healthy subjects (12♀, 15♁) provided both STEAM MRS at 7T measuring glutamate concentrations in the dACC as well as a functional magnetic resonance imaging (fMRI) task to study the influence on content-related salience processing and expectedness. Salience was modulated for both sexual and non-sexual emotional photos in either expected or unexpected situations. Correlation between MRS and task fMRI was investigated by performing regression analyses controlling for age, gender, and gray matter partial volume. Results/Conclusion: During picture processing, the extent of deactivation in the Posterior Cingulate Cortex (PCC) was attenuated by two different salience attributions: sexual content and unexpectedness of emotional content. Our results indicate that stimulus inherent salience induces an attenuation of the deactivation in PCC, which is in turn balanced by higher level of glutamate in the dACC.

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 Dates: 2019-092019-10
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
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 Identifiers: DOI: 10.3389/fnbeh.2019.00232
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Title: Frontiers in Behavioral Neuroscience
  Abbreviation : Front Behav Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 13 Sequence Number: 232 Start / End Page: 1 - 12 Identifier: ISSN: 1662-5153
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5153