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  Connectivity-based predictions of hand motor outcome for patients at the subacute stage after stroke

Lindow, J., Domin, M., Grothe, M., Horn, U., Eickhoff, S. B., & Lotze, M. (2016). Connectivity-based predictions of hand motor outcome for patients at the subacute stage after stroke. Frontiers in Human Neuroscience, 10: 101. doi:10.3389/fnhum.2016.00101.

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Lindow, Julia1, Author
Domin, Martin1, Author
Grothe, Matthias2, Author
Horn, Ulrike1, Author           
Eickhoff, Simon B.3, 4, Author
Lotze, Martin1, Author
Affiliations:
1Center for Diagnostic Radiologyand Neuroradiology, Ernst Moritz Arndt University of Greifswald, Germany, ou_persistent22              
2Department of Neurology, Ernst Moritz Arndt University of Greifswald, Germany, ou_persistent22              
3Institute for Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Germany, ou_persistent22              
4Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              

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Free keywords: Diffusion weighted imaging; Motor outcome; Prediction; Recovery; Resting state fMRI; Stroke
 Abstract: Background: Connectivity-based predictions of hand motor outcome have been proposed to be useful in stroke patients. We intended to assess the prognostic value of different imaging methods on short-term (3 months) and long-term (6 months) motor outcome after stroke. Methods: We measured resting state functional connectivity (rsFC), diffusion weighted imaging (DWI) and grip strength in 19 stroke patients within the first days (5–9 days) after stroke. Outcome measurements for short-term (3 months) and long-term (6 months) motor function was assessed by the Motricity Index (MI) of the upper limb and the box and block test (BB). Patients were predominantly mildly affected since signed consent was necessary at inclusion. We performed a multiple stepwise regression analysis to compare the predictive value of rsFC, DWI and clinical measurements. Results: Patients showed relevant improvement in both motor outcome tests. As expected grip strength at inclusion was a predictor for short- and long-term motor outcome as assessed by MI. Diffusion-based tract volume (DTV) of the tracts between ipsilesional primary motor cortex and contralesional anterior cerebellar hemisphere showed a strong trend (p = 0.05) for a predictive power for long-term motor outcome as measured by MI. DTV of the interhemispheric tracts between both primary motor cortices was predictive for both short- and long-term motor outcome in BB. rsFC was not associated with motor outcome. Conclusions: Grip strength is a good predictor of hand motor outcome concerning strength-related measurements (MI) for mildly affected subacute patients. Therefore additional connectivity measurements seem to be redundant in this group. Using more complex movement recruiting bilateral motor areas as an outcome parameter, DTV and in particular interhemispheric pathways might enhance predictive value of hand motor outcome.

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Language(s): eng - English
 Dates: 2015-11-272016-02-252016-03-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fnhum.2016.00101
BibTex Citekey: lindow_connectivity-based_2016
PMID: 27014032
PMC: PMC4783389
 Degree: -

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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
 Creator(s):
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 10 Sequence Number: 101 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5161