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  An object location memory paradigm for older adults with and without mild cognitive impairment

Külzow, N., Kerti, L., Witte, A. V., Kopp, U., Breitenstein, C., & Flöel, A. (2014). An object location memory paradigm for older adults with and without mild cognitive impairment. Journal of Neuroscience Methods, 237, 16-25. doi:10.1016/j.jneumeth.2014.08.020.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-C126-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-C127-6
Genre: Journal Article

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 Creators:
Külzow, Nadine1, Author
Kerti, Lucia2, Author
Witte, A. Veronica1, Author              
Kopp, Ute2, Author
Breitenstein, Caterina3, Author
Flöel, Agnes4, Author
Affiliations:
1Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
2NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
3Department of Neurology, Münster University, Germany, ou_persistent22              
4Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              

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Free keywords: Ageing; Associative learning; Cognitive mild impairment; Non-invasive brain stimulation; Transcranial direct current stimulation; Visuospatial memory
 Abstract: Background Object-location memory is critical in every-day life and known to deteriorate early in the course of neurodegenerative disease. New method We adapted the previously established learning paradigm “LOCATO” for use in healthy older adults and patients with mild cognitive impairment (MCI). Pictures of real-life buildings were associated with positions on a two-dimensional street map by repetitions of “correct” object-location pairings over the course of five training blocks, followed by a recall task. Correct/incorrect associations were indicated by button presses. The original two 45-item sets were reduced to 15 item-sets, and tested in healthy older adults and MCI for learning curve, recall, and re-test effects. Results The two 15-item versions showed comparable learning curves and recall scores within each group. While learning curves increased linearly in both groups, MCI patients performed significantly worse on learning and recall compared to healthy controls. Re-testing after 6 month showed small practice effects only. Comparison with existing methods LOCATO is a simple standardized task that overcomes several limitation of previously employed visuospatial task by using real-life stimuli, minimizing verbal encoding, avoiding fine motor responses, combining explicit and implicit statistical learning, and allowing to assess learning curve in addition to recall. Conclusions Results show that the shortened version of LOCATO meets the requirements for a robust and ecologically meaningful assessment of object-location memory in older adults with and without MCI. It can now be used to systematically assess acquisition of object-location memory and its modulation through adjuvant therapies like pharmacological or non-invasive brain stimulation.

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Language(s): eng - English
 Dates: 2014-08-202014-06-182014-08-212014-08-282014-11-30
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.jneumeth.2014.08.020
PMID: 25176026
Other: Epub 2014
 Degree: -

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Title: Journal of Neuroscience Methods
  Other : J. Neurosci. Meth.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 237 Sequence Number: - Start / End Page: 16 - 25 Identifier: ISSN: 0165-0270
CoNE: https://pure.mpg.de/cone/journals/resource/954925480594