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  Early detection and monitoring of cerebral ischemia using calcium-responsive MRI probes

Savić, T., Gambino, G., Bokharaie, V., Noori, H., Logothetis, N., & Angelovski, G. (2019). Early detection and monitoring of cerebral ischemia using calcium-responsive MRI probes. Proceedings of the National Academy of Sciences of the United States of America, 116(41), 20666-20671. doi:10.1073/pnas.1908503116.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0004-BECE-F Versions-Permalink: https://hdl.handle.net/21.11116/0000-0004-D286-7
Genre: Zeitschriftenartikel

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https://www.pnas.org/content/pnas/116/41/20666.full.pdf (Verlagsversion)
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 Urheber:
Savić, T1, 2, Autor           
Gambino, G1, 2, Autor           
Bokharaie, VS2, 3, Autor           
Noori, HR2, 3, Autor           
Logothetis, NK2, 4, Autor           
Angelovski, G1, 2, Autor           
Affiliations:
1Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Research Group Neuronal Convergence, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528694              
4Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Zusammenfassung: Cerebral ischemia is one of the leading causes of mortality and disability in infants and adults and its timely diagnosis is essential for an efficient treatment. We present a methodology for fast detection and real-time monitoring of fluctuations of calcium ions associated with focal ischemia using a molecular functional MRI approach. We used a dinuclear paramagnetic gadolinium(III) complex chelate that changes MR image contrast through its reversible interaction with extracellular calcium ions, while applying a remote transient middle cerebral artery occlusion as a model for ischemic stroke. Our method sensitively recognizes the onset and follows the dynamics of the ischemic core and penumbra with submillimeter spatial and second-scale temporal resolution, thus paving the way for noninvasive monitoring and development of targeted treatment strategies for cerebral ischemia.

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 Datum: 2019-092019-10
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1073/pnas.1908503116
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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : Proc. Acad. Sci. USA
  Andere : Proc. Acad. Sci. U.S.A.
  Andere : Proceedings of the National Academy of Sciences of the USA
  Kurztitel : PNAS
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: - Band / Heft: 116 (41) Artikelnummer: - Start- / Endseite: 20666 - 20671 Identifikator: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230