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  Early detection and monitoring of cerebral ischemia using calcium-responsive MRI probes

Savić, T., Gambino, G., Bokharaie, V., Noori, H., Logothetis, N., & Angelovski, G. (2019). Early detection and monitoring of cerebral ischemia using calcium-responsive MRI probes. Proceedings of the National Academy of Sciences of the United States of America, 116(41), 20666-20671. doi:10.1073/pnas.1908503116.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-BECE-F Version Permalink: https://hdl.handle.net/21.11116/0000-0004-D286-7
Genre: Journal Article

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https://www.pnas.org/content/pnas/116/41/20666.full.pdf (Publisher version)
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 Creators:
Savić, T1, 2, Author           
Gambino, G1, 2, Author           
Bokharaie, VS2, 3, Author           
Noori, HR2, 3, Author           
Logothetis, NK2, 4, Author           
Angelovski, G1, 2, Author           
Affiliations:
1Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Research Group Neuronal Convergence, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528694              
4Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: Cerebral ischemia is one of the leading causes of mortality and disability in infants and adults and its timely diagnosis is essential for an efficient treatment. We present a methodology for fast detection and real-time monitoring of fluctuations of calcium ions associated with focal ischemia using a molecular functional MRI approach. We used a dinuclear paramagnetic gadolinium(III) complex chelate that changes MR image contrast through its reversible interaction with extracellular calcium ions, while applying a remote transient middle cerebral artery occlusion as a model for ischemic stroke. Our method sensitively recognizes the onset and follows the dynamics of the ischemic core and penumbra with submillimeter spatial and second-scale temporal resolution, thus paving the way for noninvasive monitoring and development of targeted treatment strategies for cerebral ischemia.

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 Dates: 2019-092019-10
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1073/pnas.1908503116
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 116 (41) Sequence Number: - Start / End Page: 20666 - 20671 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230