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  Iron-induced relaxation mechanisms in the human substantia nigra: Towards quantifying iron load in dopaminergic neurons

Brammerloh, M., Weigelt, I., Arendt, T., Gavriilidis, F., Scherf, N., Jankuhn, S., et al. (2018). Iron-induced relaxation mechanisms in the human substantia nigra: Towards quantifying iron load in dopaminergic neurons. In Proceedings of the ISMRM 26th Annual Meeting & Exhibition.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-C222-A Version Permalink: https://hdl.handle.net/21.11116/0000-0004-C223-9
Genre: Meeting Abstract

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 Creators:
Brammerloh, Malte1, 2, Author           
Weigelt, Isabel, Author
Arendt, Thomas3, Author
Gavriilidis, Filippos1, Author           
Scherf, Nico1, Author           
Jankuhn, Steffen2, Author
Morawski, Markus4, Author           
Weiskopf, Nikolaus1, 2, Author           
Kirilina, Evgeniya1, 5, Author           
Affiliations:
1Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
2Faculty of Physics and Earth Sciences, Leipzig University, Leipzig, Germany, ou_persistent22              
3Paul Flechsig Institute of Brain Research, Leipzig, Germany, ou_persistent22              
4External Organizations, ou_persistent22              
5Center for Cognitive Neuroscience Berlin, Freie Universität Berlin, Berlin, Germany, ou_persistent22              

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Free keywords: Nigrosome; Neuromelanin; Ferritin; Ion beam microscopy
 Abstract: Pathological iron accumulation in the human brain is a biomarker for neurodegeneration. Several diagnostically promising MR-
based methods for in vivo iron quantification were proposed, based on the empirical relationship between R 2 * and iron
concentration. However, these do not account for different chemical forms and cellular distribution of iron. We combined post
mortem MRI, advanced quantitative histology and biophysical modeling to develop a generative theory linking obtained iron
concentrations to quantitative MR parameters. The impact of nanoscale molecular interaction of water with iron and of iron-rich
dopaminergic neurons was quantified in substantia nigra.

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Language(s): eng - English
 Dates: 2017-11-072018-02-072018-04-01
 Publication Status: Published online
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Place of Event: Paris Expo Porte de Versailles
Start-/End Date: 2018-06-16 - 2019-06-21

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Title: Proceedings of the ISMRM 26th Annual Meeting & Exhibition
Source Genre: Proceedings
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