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  A de novo evolved gene in the house mouse regulates female pregnancy cycles

Xie, C., Bekpen, C., Künzel, S., Keshavarz, M., Krebs-Wheaton, R., Skrabar, N., et al. (2019). A de novo evolved gene in the house mouse regulates female pregnancy cycles. eLife, 8: e44392. doi:10.7554/eLife.44392.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-C18A-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-C18B-5
Genre: Journal Article

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 Creators:
Xie, Chen1, Author              
Bekpen, Cemalettin1, Author              
Künzel, Sven1, Author              
Keshavarz, Maryam1, Author              
Krebs-Wheaton, Rebecca1, Author              
Skrabar, Neva1, Author              
Ullrich, Kristian Karsten1, Author              
Tautz, Diethard1, Author              
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Free keywords: gene evolution, mouse knockout, phenotyping, transcriptomes
 Abstract: The de novo emergence of new genes has been well documented through genomic analyses. However, a functional analysis, especially of very young protein-coding genes, is still largely lacking. Here, we identify a set of house mouse-specific protein-coding genes and assess their translation by ribosome profiling and mass spectrometry data. We functionally analyze one of them, ̑extitGm13030}, which is specifically expressed in females in the oviduct. The interruption of the reading frame affects the transcriptional network in the oviducts at a specific stage of the estrous cycle. This includes the upregulation of ̑extit{Dcpp} genes, which are known to stimulate the growth of preimplantation embryos. As a consequence, knockout females have their second litters after shorter times and have a higher infanticide rate. Given that ̑extit{Gm13030 shows no signs of positive selection, our findings support the hypothesis that a de novo evolved gene can directly adopt a function without much sequence adaptation.

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Language(s): eng - English
 Dates: 2018-12-132019-08-212019-08-222019-08
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.7554/eLife.44392
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Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)

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Title: eLife
Source Genre: Journal
 Creator(s):
Perry, George H, Editor
Weigel, Detlef, Editor
Perry, George H, Editor
Menke, Douglas B, Editor
Affiliations:
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 8 Sequence Number: e44392 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X