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  Enhancing the biocompatibility of siliconepolycarbonate urethane based implant materials

Athanasopulu, K., Kutuzova, L., Thiel, J., Lorenz, G., & Kemkemer, R. (2019). Enhancing the biocompatibility of siliconepolycarbonate urethane based implant materials. Current Directions in Biomedical Engineering, 2(1), 453-456. doi:10.1515/cdbme-2019-0114.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-C1CA-E Version Permalink: http://hdl.handle.net/21.11116/0000-0004-C1CB-D
Genre: Journal Article

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CurrDirektBiomedEngin_5_2019_453.pdf (Any fulltext), 924KB
 
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 Creators:
Athanasopulu , Kiriaki, Author
Kutuzova, Larysa, Author
Thiel, Joana, Author
Lorenz, Günter, Author
Kemkemer, Ralf1, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

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Free keywords: PURs; surface modification; hyaluronic acid
 Abstract: Polyurethane-bases block copolymers (TPCUs) are block-copolymers with systematically varied soft and hard segments. They have been suggested to serve as material for chondral implants in joint regeneration. Such applications may require the adhesion of chondrocytes to the implant surface, facilitating cell growth while keeping their phenotype. Thus, aims of this work were (i) to modify the surface of soft biostable polyurethane-based model implants (TPCU and TSiPCU) with high-molecular weight hyaluronic acid (HA) using an optimized multistep strategy of immobilization, and (ii) to evaluate bioactivity of the modified TPCUs in vitro. Our results show no cytotoxic potential of the TPCUs. HAbioactive molecules (Mw =700kDa) were immobilized onto the polyurethane surface via polyethylenimine (PEI) spacers, and modifications were confirmed by several characterization methods. Tests with porcine chondrocytes indicated the potential of the TPCU-HA for inducing enhanced cell proliferation.

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Language(s): eng - English
 Dates: 2019-09-182019-09-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1515/cdbme-2019-0114
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Title: Current Directions in Biomedical Engineering
Source Genre: Journal
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Publ. Info: Berlin : De Gruyter
Pages: - Volume / Issue: 2 (1) Sequence Number: - Start / End Page: 453 - 456 Identifier: ISSN: 2364-5504
CoNE: https://pure.mpg.de/cone/journals/resource/2364-5504