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  Cerebellar lobule atrophy and disability in progressive MS

Cocozza, S., Petracca, M., Mormina, E., Buyukturkoglu, K., Podranski, K., Heinig, M. M., et al. (2017). Cerebellar lobule atrophy and disability in progressive MS. Journal of Neurology, Neurosurgery & Psychiatry, 88(12), 1065-1072. doi:10.1136/jnnp-2017-316448.

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Cocozza, Sirio1, 2, Author
Petracca, Maria1, 3, Author
Mormina, Enricomaria1, 4, Author
Buyukturkoglu, Korhan1, Author
Podranski, Kornelius1, Author           
Heinig, Monika M1, Author
Pontillo, Giuseppe2, Author
Russo, Camilla2, Author
Tedeschi, Enrico2, Author
Russo, Cinzia Valeria3, Author
Costabile, Teresa3, Author
Lanzillo, Roberta3, Author
Harel, Asaff1, Author
Klineova, Sylvia1, Author
Miller, Aaron2, Author
Brunetti, Arturo3, Author
Morra, Vincenzo Brescia1, Author
Lublin, Fred1, Author
Inglese, Matilde5, 6, 7, Author
1Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA, ou_persistent22              
2Department of Advanced Biomedical Sciences, University of Naples Federico II, Italy, ou_persistent22              
3Department of Neurosciences, Reproductive and Odonto-stomatological Sciences, University of Naples Federico II, Italy, ou_persistent22              
4Department of Biomedical Sciences and Morphological and Functional Images, University of Messina, Italy, ou_persistent22              
5Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA, ou_persistent22              
6Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Perinatal Sciences, University of Genova, Italy, ou_persistent22              
7Scientific Institute for Research, Hospitalization and Health Care (IRCCS), Genova, Italy, ou_persistent22              


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 Abstract: Objective To investigate global and lobular cerebellar volumetries in patients with progressive multiple sclerosis (MS), testing the contribution of cerebellar lobular atrophy to both motor and cognitive performances.

Methods Eighty-two patients with progressive MS and 46 healthy controls (HC) were enrolled in this cross-sectional study. Clinical evaluation included motor and cognitive testing: Expanded Disability Status Scale, cerebellar Functional System score, Timed 25-Foot Walk Test, 9-Hole Peg Test (9-HPT), Symbol Digit Modalities Test (SDMT), Brief Visuospatial Memory Test–Revised (BVMT) and California Verbal Learning Test II (CVLT). Cerebellar volumes were automatically obtained using the Spatially Unbiased Infratentorial Toolbox. A hierarchical multiple linear regression analysis was performed to assess the relationship between MRI variables of supratentorial and cerebellar damage (grey matter fraction, T2 lesion volume, metrics of cerebellar atrophy and cerebellar lesion volume) and motor/cognitive scores.

Results Patients with MS exhibited lower cerebellar volumes compared with HC. Regression analysis showed that cerebellar metrics accounted for extra variance in both motor and cognitive performances, with cerebellar lesion volume, cerebellar Lobules VI, Crus I and VIIIa atrophy being independent predictors of 9-HPT, SDMT, BVMT and CVLT performances.

Conclusions Atrophy of specific cerebellar lobules explains different aspects of motor and cognitive disability in patients with progressive MS. Investigation of cerebellar involvement provides further insight into the pathophysiological basis of clinical disability in progressive MS.


Language(s): eng - English
 Dates: 2017-07-102017-05-162018-07-232017-11-282017-08-26
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1136/jnnp-2017-316448
PMID: 28844067
Other: Epub 2017
 Degree: -



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Project information

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Project name : -
Grant ID : NMSS RG 5120A3/1
Funding program : -
Funding organization : National Multiple Sclerosis Society
Project name : -
Funding program : -
Funding organization : Novartis Pharmaceuticals
Project name : -
Grant ID : -
Funding program : -
Funding organization : Noto Foundation

Source 1

Title: Journal of Neurology, Neurosurgery & Psychiatry
Source Genre: Journal
Publ. Info: London : British Medical Association
Pages: - Volume / Issue: 88 (12) Sequence Number: - Start / End Page: 1065 - 1072 Identifier: ISSN: 0022-3050
CoNE: https://pure.mpg.de/cone/journals/resource/111085522793000