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  Antibiotic resistance in Pseudomonas aeruginosa – Mechanisms, epidemiology and evolution

Botelho, J., Grosso, F., & Peixe, L. (2019). Antibiotic resistance in Pseudomonas aeruginosa – Mechanisms, epidemiology and evolution. Drug Resistance Updates, 44, 26-47. doi:10.1016/j.drup.2019.07.002.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0004-C3E6-C 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0004-C3E7-B
資料種別: 学術論文

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1-s2.0-S1368764619300238-main.pdf (出版社版), 3MB
 
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制限付き (公開猶予期限 2020-07-19) (Max Planck Institute for Evolutionary Biology, MPLM; )
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 作成者:
Botelho, João1, 著者           
Grosso, Filipa, 著者
Peixe, Luísa, 著者
所属:
1Max Planck Fellow Group Antibiotic Resistance Evolution, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2600692              

内容説明

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キーワード: Pseudomonas aeruginosa; Antibiotic resistance, Integrative and conjugative elements, Plasmids, Fitness cost
 要旨: Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate use of these medicines has driven the dissemination of antibiotic resistance (AR) in most bacteria. Pseudomonas aeruginosa is an opportunistic pathogen commonly involved in environmental- and difficult-to-treat hospital-acquired infections. This species is frequently resistant to several antibiotics, being in the “critical” category of the WHO's priority pathogens list for research and development of new antibiotics. In addition to a remarkable intrinsic resistance to several antibiotics, P. aeruginosa can acquire resistance through chromosomal mutations and acquisition of AR genes. P. aeruginosa has one of the largest bacterial genomes and possesses a significant assortment of genes acquired by horizontal gene transfer (HGT), which are frequently localized within integrons and mobile genetic elements (MGEs), such as transposons, insertion sequences, genomic islands, phages, plasmids and integrative and conjugative elements (ICEs). This genomic diversity results in a non-clonal population structure, punctuated by specific clones that are associated with significant morbidity and mortality worldwide, the so-called high-risk clones. Acquisition of MGEs produces a fitness cost in the host, that can be eased over time by compensatory mutations during MGE-host coevolution. Even though plasmids and ICEs are important drivers of AR, the underlying evolutionary traits that promote this dissemination are poorly understood. In this review, we provide a comprehensive description of the main strategies involved in AR in P. aeruginosa and the leading drivers of HGT in this species. The most recently developed genomic tools that allowed a better understanding of the features contributing for the success of P. aeruginosa are discussed.

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言語: eng - English
 日付: 2019-07-112019-04-232019-07-122019-07-192019
 出版の状態: 出版
 ページ: -
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 識別子(DOI, ISBNなど): DOI: 10.1016/j.drup.2019.07.002
 学位: -

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出版物 1

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出版物名: Drug Resistance Updates
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: Elsevier
ページ: - 巻号: 44 通巻号: - 開始・終了ページ: 26 - 47 識別子(ISBN, ISSN, DOIなど): その他: 1532-2084
ISSN: 1368-7646
CoNE: https://pure.mpg.de/cone/journals/resource/1368-7646