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  Trace element mapping in Parkinsonian brain by quantitative ion beam microscopy

Barapatre, N., Morawski, M., Butz, T., & Reinert, T. (2010). Trace element mapping in Parkinsonian brain by quantitative ion beam microscopy. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 268(11-12), 2156-2159. doi:10.1016/j.nimb.2010.02.039.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-CE19-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-CE1A-8
Genre: Journal Article

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 Creators:
Barapatre, Nirav1, Author
Morawski, Markus1, Author
Butz, Tilman1, Author
Reinert, Tilo1, Author              
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: Beam current monitoring; PIXE; Quantitative microscopy; Trace element analysis; Charge measurement; Parkinson’s disease
 Abstract: The role of iron in the pathogenesis of the Parkinson’s disease (PD) is a current subject of research in Neurochemistry, since an abnormal increase in iron is reported in the substantia nigra (SN) of Parkinsonian patients. A severe loss of the cells containing dopamine in the SN in the PD has also drawn attention towards the function of a browny-black pigment called neuromelanin, which accumulates predominantly in these dopaminergic neurons. The neuromelanin has an ability to chelate metal ions, which, in free state, may cause considerable damage to cells by reacting with their lipid-rich membranes. However, it could also potentiate free radical production if it releases the bound metal ions. The highly sensitive and non-destructive micro-PIXE method suits best to quantify and map the trace elements in the SN. The accuracy in charge measurement for such microanalysis studies is of utmost importance for quantitative analysis. Since a Faraday cup is usually placed behind the thin biological sample to measure the charge, the primary and the secondary electrons, knocked out from the sample by traversing ion beam, hamper an exact charge determination. Hence, a new non-interceptive technique was developed for precise charge measurement and for continuous monitoring of beam current.

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Language(s): eng - English
 Dates: 2010-02-252010-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.nimb.2010.02.039
BibTex Citekey: Barapatre:2010
 Degree: -

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Title: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
  Abbreviation : NIM B
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier B.V.
Pages: - Volume / Issue: 268 (11-12) Sequence Number: - Start / End Page: 2156 - 2159 Identifier: ISSN: 0168-583X
CoNE: https://pure.mpg.de/cone/journals/resource/954925484704