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  Is there penetration of titania nanoparticles in sunscreens through skin?: A comparative electron and ion microscopy study

Gontier, E., Ynsa, M.-D., Biró, T., Hunyadi, J., Kiss, B., Gáspár, K., et al. (2008). Is there penetration of titania nanoparticles in sunscreens through skin?: A comparative electron and ion microscopy study. Nanotoxicology, 2(4), 218-231. doi:10.1016/j.nimb.2009.03.039.

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 Creators:
Gontier, Etienne1, Author
Ynsa, Maria-Dolores1, Author
Biró, Tamás1, Author
Hunyadi, Janos1, Author
Kiss, Borbala1, Author
Gáspár, Krisztián1, Author
Pinheiro, Teresa1, Author
Silva, Joao-Nuno1, Author
Filipe, Paulo1, Author
Stachura, Jerzy1, Author
Dabros, Wojciech1, Author
Reinert, Tilo1, Author              
Butz, Tilman1, Author
Moretto, Philippe1, Author
Surlève-Bazeille, Jean-Etienne 1, Author
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: Electron microscopy; ion microscopy; TiO2 nanoparticles; mammalian skin
 Abstract: We report on a comparative study by Transmission Electron Microscopy (HRTEM) and Scanning Transmission Ion Microscopy (STIM) combined with Rutherford Backscattering Spectrometry (RBS) and Particle Induced X-Ray Emission (PIXE) on ultra-thin and thin cross-sections, respectively, of various skin samples (porcine skin, healthy human skin, human skin grafted on a severe combined immuno-deficient mouse model) to which we applied topically various formulations containing titanium dioxide (TiO2) nanoparticles with primary particle sizes in the range from 20–100 nm. Whereas the HRTEM and STIM/PIXE images reveal clear differences – mainly related to the different thickness of the cross-sections – they unambiguously show that penetration of TiO2 nanoparticles is restricted to the topmost 3–5 corneocyte layers of the stratum corneum (SC).

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Language(s): eng - English
 Dates: 2009-07-102008-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.nimb.2009.03.039
BibTex Citekey: Gontier:2008
 Degree: -

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Title: Nanotoxicology
Source Genre: Journal
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Publ. Info: Oxon, England : Taylor & Francis Ltd
Pages: - Volume / Issue: 2 (4) Sequence Number: - Start / End Page: 218 - 231 Identifier: ISSN: 1743-5390
CoNE: https://pure.mpg.de/cone/journals/resource/1743-5390