English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  High resolution quantitative element mapping of neuromelanin-containing neurons

Reinert, T., Fiedler, A., Morawski, M., & Arendt, T. (2007). High resolution quantitative element mapping of neuromelanin-containing neurons. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 260(1), 227-230. doi:10.1016/j.nimb.2007.02.070.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0004-CED7-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-CED8-1
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Reinert, Tilo1, Author              
Fiedler, Anja1, Author
Morawski, Markus1, Author
Arendt, Thomas1, Author
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: Neuromelanin; Iron; Quantitative analysis; Submicron resolution
 Abstract: Neuromelanin is a dark coloured intracellular pigment that appears in a specific population of neurons (dopaminergic and noradrenergic) predominantly in the substantia nigra and in the locus coeruleus. In recent years, there is increasing interest in the role of neuromelanin because of a hypothesised link between this pigment and the cell death of neuromelanin-containing neurons in Parkinson's disease (PD). Therefore, the role of neuromelanin in the pathology of \PD\ is an actual focus in neuroscience. We have investigated the elemental contents and distributions of sulphur, calcium, iron, nickel and copper of neuromelanin in dopaminergic neurons for a Parkinson case and a control case (in situ, 6xa0;μm brain sections). There was no difference in the iron concentration between the two cases. However, the calcium concentration was 3-fold higher in the Parkinson case, whereas the copper and nickel concentrations decreased. An ultrastructural investigation of the concentrations of calcium and iron within the neuromelanin suggests that these two elements are not necessarily co-localized.

Details

show
hide
Language(s): eng - English
 Dates: 2007-02-162007-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.nimb.2007.02.070
BibTex Citekey: Reinert:2007
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
  Abbreviation : NIM B
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam : Elsevier B.V.
Pages: - Volume / Issue: 260 (1) Sequence Number: - Start / End Page: 227 - 230 Identifier: ISSN: 0168-583X
CoNE: https://pure.mpg.de/cone/journals/resource/954925484704