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Schlagwörter:
brain research; iron; life sciences; Mössbauer effect; particle induced X-ray emission; perineuronal nets
Zusammenfassung:
Abstractnbsp;nbsp;A specialized form of extracellular matrix (ECM) surrounds subpopulations of neurons termed `perineuronal nets' (PNs). These
PNs form highly anionic charged structures in the direct microenvironment of neurons, assumed to be involved in local ion
homeostasis since they are able to scavenge and bind redox--active iron ions. The quantity and distribution of iron--charged
PNs of the extracellular matrix in the rat brain areas of the cortex and the red nucleus was investigated using the powerful
combination of Particle--Induced X--ray Emission (PIXE) and M?ssbauer spectroscopy. These studies reveal that the iron is bound
to the PNs as Fe(III). PNs in both brain regions accumulate up to three to five times more Fe3+ than any other tissue structure in dependency on the applied Fe concentration with local amount maximums of 480nbsp;mmol/l Fe
at PNs.