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  Pan-embryo cell dynamics of germlayer formation in zebrafish

Shah, G., Thierbach, K., Schmid, B., Reade, A., Roeder, I., Scherf, N., et al. (2017). Pan-embryo cell dynamics of germlayer formation in zebrafish. bioRxiv. doi:10.1101/173583.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-C68C-F Version Permalink: http://hdl.handle.net/21.11116/0000-0005-6280-B
Genre: Paper

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Shah, Gopi1, Author
Thierbach, Konstantin1, Author              
Schmid, Benjamin1, Author
Reade, Anna1, Author
Roeder, Ingo1, Author
Scherf, Nico1, Author              
Huisken, Jan1, Author
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1External Organizations, ou_persistent22              

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 Abstract: Cell movements are coordinated across spatio-temporal scales to achieve precise positioning of organs during vertebrate gastrulation. In zebrafish, mechanisms governing such morphogenetic movements have so far only been studied within a local region or a single germlayer. Here, we present pan-embryo analyses of fate specification and dynamics of all three germlayers simultaneously within a gastrulating embryo, showing that cell movement characteristics are predominantly determined by its position within the embryo, independent of its germlayer identity. The spatially confined fate specification establishes a distinct distribution of cells in each germlayer during early gastrulation. The differences in the initial distribution are subsequently amplified by a unique global movement, which organizes the organ precursors along the embryonic body axis, giving rise to the blueprint of organ formation.

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Language(s): eng - English
 Dates: 2017-08-09
 Publication Status: Published online
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 Rev. Type: No review
 Identifiers: DOI: 10.1101/173583
BibTex Citekey: Shah173583
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Title: bioRxiv
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