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  Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage

Kaucka, M., Petersen, J., Tesarova, M., Szarowska, B., Kastriti, M. E., Xie, M., et al. (2018). Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage. eLife, 7: e34465. doi:10.7554/eLife.34465.

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 Creators:
Kaucka, Marketa1, Author           
Petersen, Julian, Author
Tesarova, Marketa, Author
Szarowska, Bara, Author
Kastriti, Maria Eleni, Author
Xie, Meng, Author
Kicheva, Anna, Author
Annusver, Karl, Author
Kasper, Maria, Author
Symmons, Orsolya, Author
Pan, Leslie, Author
Spitz, Francois, Author
Kaiser, Jozef, Author
Hovorakova, Maria, Author
Zikmund, Tomas, Author
Sunadome, Kazunori, Author
Matise, Michael P, Author
Wang, Hui, Author
Marklund, Ulrika, Author
Abdo, Hind, Author
Ernfors, Patrik, AuthorMaire, Pascal, AuthorWurmser, Maud, AuthorChagin, Andrei S, AuthorFried, Kaj, AuthorAdameyko, Igor, Author more..
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1External Organizations, ou_persistent22              

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Free keywords: mammalian face, facial shaping, embryonic development, cartilage induction, sonic hedgehog, cleft palate
 Abstract: Facial shape is the basis for facial recognition and categorization. Facial features reflect the underlying geometry of the skeletal structures. Here, we reveal that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped by signals generated by neural structures: brain and olfactory epithelium. Brain-derived Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior nasal capsule, whereas the formation of a capsule roof is controlled by signals from the olfactory epithelium. Unexpectedly, the cartilage of the nasal capsule turned out to be important for shaping membranous facial bones during development. This suggests that conserved neurosensory structures could benefit from protection and have evolved signals inducing cranial cartilages encasing them. Experiments with mutant mice revealed that the genomic regulatory regions controlling production of SHH in the nervous system contribute to facial cartilage morphogenesis, which might be a mechanism responsible for the adaptive evolution of animal faces and snouts.

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Language(s): eng - English
 Dates: 2017-12-192018-06-122018-06-132018-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.7554/eLife.34465
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Title: eLife
Source Genre: Journal
 Creator(s):
White, Richard M, Editor
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 7 Sequence Number: e34465 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X