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  Early Developmental Tonotopic Mapping of the Mouse Auditory Midbrain with Mn-Enhanced MRI

Yu, X., Sanes, D., Zou, J., & Turnbull, D. (2006). Early Developmental Tonotopic Mapping of the Mouse Auditory Midbrain with Mn-Enhanced MRI. Poster presented at 29th Annual MidWinter Meeting of the Association for Research in Otolaryngology (ARO 2006), Baltimore, MD, USA.

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Yu, X1, Author           
Sanes, D, Author
Zou, J, Author
Turnbull, DH, Author
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1External Organizations, ou_persistent22              

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 Abstract: Our previous studies have established the utility of Mn-enhanced MRI (MEMRI) to detect the pattern and magnitude of sound-evoked activity within the mouse inferior colliculus (IC) (Yu et al. Nature Neuroscience 8:961-8, 2005). We have now extended this analysis to compare frequency-dependent activation patterns in juvenile mice. The maturation of two frequency-dependent patterns was compared in animals at postnatal (P) days 13, 16, and 19. Following Mn injections, mice were exposed 24 hours in free field of either 40 kHz or 16 kHz stimulation with amplitude modulated between 65 and 89 dB SPL. Since MEMRI produces 3-D image data, statistical analysis has enabled quantification of 3-D IC activity in the form of voxel-by-voxel comparison of the frequency dependent activity patterns. At P13, the activity patterns of the two pure tones are indistinguishable from one another. This was confirmed with a voxel-by-voxel statistical comparison of the two patterns. At P16, the activation patterns were not as distinct from one another. The voxel-by-voxel statistical comparison indicated that the two stimuli elicited different patterns of activity in the ventral IC (i.e., the presumptive 40 kHz region), but not more dorsally (i.e., the presumptive 16 kHz region). At P19, the activity patterns evoked by each tone are clearly separated. MEMRI shows that the spatial pattern of activity evoked by 40 kHz stimulation resolved to a clear ventro-caudal contour in the IC. The spatial pattern evoked by a 16 kHz stimulus was similar in shape, but located in a more dorsal position, as expected from previous electrophysiological characterizations. Thus, MEMRI revealed a clear maturation of frequency-specific responses within the mouse IC. These results can form the basis for future analyses of altered tonotopy following genetic or environmental manipulations.

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 Dates: 2006-02
 Publication Status: Published online
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Title: 29th Annual MidWinter Meeting of the Association for Research in Otolaryngology (ARO 2006)
Place of Event: Baltimore, MD, USA
Start-/End Date: 2006-02-05 - 2006-02-09

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Title: 29th Annual MidWinter Meeting of the Association for Research in Otolaryngology (ARO 2006)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 106 - 107 Identifier: -