English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Brain damage with heart failure: Cardiac biomarker alterations and gray matter decline

Mueller, K., Thiel, F., Beutner, F., Teren, A., Frisch, S., Ballarini, T., et al. (2020). Brain damage with heart failure: Cardiac biomarker alterations and gray matter decline. Circulation Research, 126(6), 750-764. doi:10.1161/CIRCRESAHA.119.315813.

Item is

Files

show Files
hide Files
:
Mueller_2020.pdf (Publisher version), 7MB
Name:
Mueller_2020.pdf
Description:
-
OA-Status:
Hybrid
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show

Creators

show
hide
 Creators:
Mueller, Karsten1, 2, Author           
Thiel, Friederike3, Author           
Beutner, Frank4, 5, Author
Teren, Andrej4, 5, Author
Frisch, Stefan3, Author           
Ballarini, Tommaso3, Author           
Möller, Harald E.1, Author           
Ihle, Kristin1, Author           
Thiery, Joachim4, 5, 6, Author
Schuler, Gerhard4, Author
Villringer, Arno3, 5, 7, Author           
Schroeter, Matthias L.3, 5, 7, Author           
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Method and Development Group Neural Data Science and Statistical Computing, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_3282987              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Heart Center, Helios Hospital, University of Leipzig, Germany, ou_persistent22              
5Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
6Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
7Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

Content

show
hide
Free keywords: Brain injury; Voxel-based morphometry; Gray matter; Magnetic resonance imaging; Brain structure
 Abstract: Rationale: Heart failure (HF) following heart damage leads to a decreased blood flow due to a reduced pump efficiency of the heart muscle. A consequence can be insufficient oxygen supply to the organism including the brain. While HF clearly shows neurological symptoms, such as fatigue, nausea and dizziness, the implications for brain structure are not well understood. Few studies show regional gray matter decrease related to HF, however, the underlying mechanisms leading to the observed brain changes remain unclear.

Objective: To study the relationship between impaired heart function, hampered blood circulation and structural brain change in a case-control study.

Methods and Results: Within a group of 80 patients of the Leipzig Heart Center, we investigated a potential correlation between HF biomarkers and the brain's gray matter density (GMD) obtained by magnetic resonance imaging. We observed a significant positive correlation between cardiac ejection fraction and GMD across the whole frontal and parietal medial cortex reflecting the consequence of HF onto the brain's gray matter. Moreover, we also obtained a relationship between GMD and the N-terminal prohormone of brain natriuretic peptide (NT-proBNP) − a biomarker that is used for screening, diagnosis and prognosis of HF. Here we found a significant negative correlation between NT-proBNP and GMD in the medial and posterior cingulate cortex but also in precuneus and hippocampus, which are key regions implicated in structural brain changes in dementia.

Conclusions: We obtained significant correlations between brain structure and markers of heart failure including EF and NT-proBNP. A diminished GMD was found with decreased EF and increased NT-proBNP in wide brain regions including the whole frontomedian cortex as well as hippocampus and precuneus. Our observations might reflect structural brain damage in areas that are related to cognition, however, whether these structural changes facilitate the development of cognitive alterations has to be proven by further longitudinal studies.

Details

show
hide
Language(s): eng - English
 Dates: 2019-05-082020-01-212020-01-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1161/CIRCRESAHA.119.315813
PMID: 31969053
Other: Epub 2020
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : LIFE—Leipzig Research Center for Civilization Diseases, University of Leipzig
Grant ID : -
Funding program : -
Funding organization : European Union; European Regional Development Fund (ERDF); Free State of Saxony
Project name : -
Grant ID : SCHR 774/5-1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : German Consortium for Frontotemporal Lobar Degeneration
Grant ID : O1GI1007A
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : PDF-IRG-1307
Funding program : -
Funding organization : Parkinson’s Disease Foundation
Project name : -
Grant ID : MJFF-11362
Funding program : -
Funding organization : Michael J Fox Foundation (MJFF)

Source 1

show
hide
Title: Circulation Research
  Other : Circ. Res.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Baltimore, Md. : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 126 (6) Sequence Number: - Start / End Page: 750 - 764 Identifier: ISSN: 0009-7330
CoNE: https://pure.mpg.de/cone/journals/resource/954925390276