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  Brain damage with heart failure: Cardiac biomarker alterations and gray matter decline

Mueller, K., Thiel, F., Beutner, F., Teren, A., Frisch, S., Ballarini, T., et al. (2020). Brain damage with heart failure: Cardiac biomarker alterations and gray matter decline. Circulation Research, 126(6), 750-764. doi:10.1161/CIRCRESAHA.119.315813.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-CC9F-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-805E-0
Genre: Journal Article

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 Creators:
Mueller, Karsten1, Author              
Thiel, Friederike2, Author              
Beutner, Frank3, 4, Author
Teren, Andrej3, 4, Author
Frisch, Stefan2, Author              
Ballarini, Tommaso2, Author              
Möller, Harald E.1, Author              
Ihle, Kristin1, Author              
Thiery, Joachim3, 4, 5, Author
Schuler, Gerhard3, Author
Villringer, Arno2, 4, 6, Author              
Schroeter, Matthias L.2, 4, 6, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Heart Center, Helios Hospital, University of Leipzig, Germany, ou_persistent22              
4Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
5Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
6Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Brain injury; Voxel-based morphometry; Gray matter; Magnetic resonance imaging; Brain structure
 Abstract: Rationale: Heart failure (HF) following heart damage leads to a decreased blood flow due to a reduced pump efficiency of the heart muscle. A consequence can be insufficient oxygen supply to the organism including the brain. While HF clearly shows neurological symptoms, such as fatigue, nausea and dizziness, the implications for brain structure are not well understood. Few studies show regional gray matter decrease related to HF, however, the underlying mechanisms leading to the observed brain changes remain unclear. Objective: To study the relationship between impaired heart function, hampered blood circulation and structural brain change in a case-control study. Methods and Results: Within a group of 80 patients of the Leipzig Heart Center, we investigated a potential correlation between HF biomarkers and the brain's gray matter density (GMD) obtained by magnetic resonance imaging. We observed a significant positive correlation between cardiac ejection fraction and GMD across the whole frontal and parietal medial cortex reflecting the consequence of HF onto the brain's gray matter. Moreover, we also obtained a relationship between GMD and the N-terminal prohormone of brain natriuretic peptide (NT-proBNP) − a biomarker that is used for screening, diagnosis and prognosis of HF. Here we found a significant negative correlation between NT-proBNP and GMD in the medial and posterior cingulate cortex but also in precuneus and hippocampus, which are key regions implicated in structural brain changes in dementia. Conclusions: We obtained significant correlations between brain structure and markers of heart failure including EF and NT-proBNP. A diminished GMD was found with decreased EF and increased NT-proBNP in wide brain regions including the whole frontomedian cortex as well as hippocampus and precuneus. Our observations might reflect structural brain damage in areas that are related to cognition, however, whether these structural changes facilitate the development of cognitive alterations has to be proven by further longitudinal studies.

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Language(s): eng - English
 Dates: 2019-05-082020-01-212020-01-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1161/CIRCRESAHA.119.315813
PMID: 31969053
Other: Epub 2020
 Degree: -

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Title: Circulation Research
  Other : Circ. Res.
Source Genre: Journal
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Publ. Info: Baltimore, Md. : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 126 (6) Sequence Number: - Start / End Page: 750 - 764 Identifier: ISSN: 0009-7330
CoNE: https://pure.mpg.de/cone/journals/resource/954925390276