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  Aversive state processing in the posterior insular cortex

Gehrlach , D. A., Dolensek , N., Klein, A. S., Chowdhury , R. R., Matthys, A., Junghänel, M., et al. (2019). Aversive state processing in the posterior insular cortex. Nature Neuroscience, 22, 1424-1437. doi:10.1038/s41593-019-0469-1.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-D80E-A Version Permalink: http://hdl.handle.net/21.11116/0000-0004-D80F-9
Genre: Journal Article

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 Creators:
Gehrlach , Daniel A.1, Author
Dolensek , Nejc1, Author
Klein, Alexandra S.1, Author
Chowdhury , Ritu Roy1, Author
Matthys, Arthur1, Author
Junghänel, Michaela1, Author
Gaitanos, Thomas N.1, Author
Podgornik, Alja1, Author
Black, Thomas D.1, Author
Vaka, Narasimha Reddy1, Author
Conzelmann , Karl-Klaus, Author
Gogolla, Nadine1, Author              
Affiliations:
1Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society, ou_2054290              

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 Abstract: Triggering behavioral adaptation upon the detection of adversity is crucial for survival. The insular cortex has been suggested to process emotions and homeostatic signals, but how the insular cortex detects internal states and mediates behavioral adaptation is poorly understood. By combining data from fiber photometry, optogenetics, awake two-photon calcium imaging and comprehensive whole-brain viral tracings, we here uncover a role for the posterior insula in processing aversive sensory stimuli and emotional and bodily states, as well as in exerting prominent top-down modulation of ongoing behaviors in mice. By employing projection-specific optogenetics, we describe an insula-to-central amygdala pathway to mediate anxiety-related behaviors, while an independent nucleus accumbens-projecting pathway regulates feeding upon changes in bodily state. Together, our data support a model in which the posterior insular cortex can shift behavioral strategies upon the detection of aversive internal states, providing a new entry point to understand how alterations in insula circuitry may contribute to neuropsychiatric conditions.

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 Dates: 2019
 Publication Status: Published in print
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 Identifiers: DOI: 10.1038/s41593-019-0469-1
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 22 Sequence Number: - Start / End Page: 1424 - 1437 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931