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  Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

Betts, J., Kirilina, E., Otaduy, C., Ivanov, D., Acosta-Cabronero, J., Callaghan, M. F., et al. (2019). Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases. Brain, 142(9), 2558-2571. doi:10.1093/brain/awz193.

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Betts, J.1, Author
Kirilina, Evgeniya1, 2, Author              
Otaduy, C.G.1, Author
Ivanov, Dimo1, Author
Acosta-Cabronero, Julio1, Author
Callaghan, Martina F.1, Author
Lambert, Christian1, Author
Cardenas-Blanco, Arturo1, Author
Pine, Kerrin1, 2, Author              
Passamonti, Luca1, Author
Loane, Clare1, Author
Keuken, Max C.1, Author
Trujillo, Paula1, Author
Lüsebrink, Falk1, Author
Mattern, Hendrik1, Author
Liu, Kathy Y.1, Author
Priovoulos, Nikos1, Author
Fliessbach, Klaus1, Author
Dahl, Martin J.1, Author
Maaß, Anne1, Author
Madelung, Christopher F.1, AuthorMeder, David1, AuthorEhrenberg, Alexander J.1, AuthorSpeck, Oliver1, AuthorWeiskopf, Nikolaus1, 2, Author              Dolan, Raymond1, AuthorInglis, Ben1, AuthorTosun, Duygu1, AuthorMorawski, Markus1, AuthorZucca, Fabio A.1, AuthorSiebner, Hartwig R.1, AuthorMather, Mara1, AuthorUludag, Kamil1, AuthorHeinsen, Helmut1, AuthorPoser, Benedikt A.1, AuthorHoward, Robert1, AuthorZecca, Luigi1, AuthorRowe, James B.1, AuthorGrinberg, Lea T.1, AuthorJacobs, Heidi I.L.1, AuthorDüzel, Emrah1, AuthorHämmerer, Dorothea1, Author more..
1External Organizations, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              


Free keywords: Locus Coeruleus (LC); Magnetic Resonance Imaging (MRI); Neurodegeneration; Noradrenaline (NA) biomarker
 Abstract: Pathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI approaches now provide an opportunity to quantify structural features of the locus coeruleus in vivo during disease progression. In combination with neuropathological biomarkers, in vivo locus coeruleus imaging could help to understand the contribution of locus coeruleus neurodegeneration to clinical and pathological manifestations in Alzheimer’s disease, atypical neurodegenerative dementias and Parkinson’s disease. Moreover, as the functional sensitivity of the noradrenergic system is likely to change with disease progression, in vivo measures of locus coeruleus integrity could provide new pathophysiological insights into cognitive and behavioural symptoms. Locus coeruleus imaging also holds the promise to stratify patients into clinical trials according to noradrenergic dysfunction. In this article, we present a consensus on how non-invasive in vivo assessment of locus coeruleus integrity can be used for clinical research in neurodegenerative diseases. We outline the next steps for in vivo, post-mortem and clinical studies that can lay the groundwork to evaluate the potential of locus coeruleus imaging as a biomarker for neurodegenerative diseases.


Language(s): eng - English
 Dates: 2019-04-122019-02-222019-05-012019-07-202019-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/brain/awz193
PMID: 31327002
PMC: PMC6736046
 Degree: -



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Project information

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Project name : Non-Invasive In-Vivo Histology in Health and Disease Using Magnetic Resonance Imaging (MRI) / HMRI
Grant ID : 616905
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial / NISCI
Grant ID : 681094
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : Entschlüsselung der pathophysiologischen Prozesse induziert durch eine Querschnittlähmung: Anwendung von MRT basierter in vivo und ex vivo Histologie / hMRIofSCI
Grant ID : 01EW1711A ; 01EW1711B
Funding program : ERA-NET NEURON
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : This are just the project information about the MPI for Human Cognitive and Brain Sciences. More information available in the paper
Grant ID : -
Funding program : -
Funding organization : -

Source 1

Title: Brain
  Other : Brain
Source Genre: Journal
Publ. Info: London : Macmillan
Pages: - Volume / Issue: 142 (9) Sequence Number: - Start / End Page: 2558 - 2571 Identifier: ISSN: 0006-8950
CoNE: https://pure.mpg.de/cone/journals/resource/954925385135