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  Transcranial magnetic stimulation of the medial prefrontal cortex decreases emotional memory schemas

Bovy, L., Berkers, R., Pottkämper, J., Varatheesvaran, R., Fernández, G., Tendolkar, I., et al. (2020). Transcranial magnetic stimulation of the medial prefrontal cortex decreases emotional memory schemas. Cerebral Cortex. doi:10.1093/cercor/bhz329.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-D375-A Version Permalink: http://hdl.handle.net/21.11116/0000-0005-9E76-5
Genre: Journal Article

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 Creators:
Bovy, Leonore1, Author
Berkers, Ruud1, 2, Author              
Pottkämper, Julia1, 3, Author
Varatheesvaran, Rathiga1, 4, Author
Fernández, Guillén1, Author
Tendolkar, Indira1, 5, Author
Drechsler, Martin1, Author
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
2Max Planck Research Group Adaptive Memory, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2295691              
3Technical Medical Centre (TechMed), University of Twente, Enschede, the Netherlands, ou_persistent22              
4Leibniz Institute for Resilience Research (LIR), Mainz, Germany, ou_persistent22              
5Department of Psychiatry, Radboud University, Nijmegen, the Netherlands, ou_persistent22              

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Free keywords: TMS; Bias; Depression; Memory; Schema
 Abstract: Memory bias for negative information is a critical characteristic of major depression, but the underlying neural mechanisms are largely unknown. The recently revived concept of memory schemas may shed new light on memory bias in depression: negative schemas might enhance the encoding and consolidation of negative experiences, thereby contributing to the genesis and perpetuation of depressive pathology. To investigate this relationship, we aimed to transiently perturb processing in the medial prefrontal cortex (mPFC), a core region involved in schema memory, using neuronavigated transcranial magnetic stimulation (TMS) targeting the mPFC. Forty healthy volunteers first underwent a negative mood induction to activate negative schema processing after which they received either active inhibitory (N = 20) or control (N = 20) stimulation to the mPFC. Then, all participants performed the encoding of an emotional false memory task. Recall and recognition performance was tested the following morning. Polysomnographic data was recorded continuously during the night before and after encoding. Secondary measures included sleep and mood questionnaires. We observed a significantly lower number of false recognition of negative critical lures following mPFC perturbation compared to the control group, whereas no differences in veridical memory performance were observed. These findings were supported by reaction time data. No relation between REM sleep and (false) emotional memory performance was observed. These findings support previous causal evidence for a role of the mPFC in schema memory processing and further suggest a role of the mPFC in memory bias.

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Language(s): eng - English
 Dates: 2019-11-122019-06-132019-12-112020-01-10
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/cercor/bhz329
Other: Epub ahead of print
PMID: 31925421
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Funding organization : Donders Center for Medical Neuroscience

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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440