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  Mucins and pathogenic mucin-like molecules are immunomodulators during infection and targets for diagnostics and vaccines

Pinzón Martín, S., Seeberger, P. H., & Varón Silva, D. (2019). Mucins and pathogenic mucin-like molecules are immunomodulators during infection and targets for diagnostics and vaccines. Frontiers in Chemistry, 7: 710. doi:10.3389/fchem.2019.00710.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-D5EC-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-56BF-3
Genre: Journal Article

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 Creators:
Pinzón Martín, Sandra1, Author              
Seeberger, Peter H.2, Author              
Varón Silva, Daniel1, Author              
Affiliations:
1Daniel Varón Silva, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863302              
2Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863308              

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Free keywords: Mucins, Mucin-like molecules, O-glycoproteins, cancer, parasites, virus, infection
 Abstract: Mucins and mucin-like molecules are highly O-glycosylated proteins present on the cell surface of mammals and other organisms. These glycoproteins are highly diverse in the apoprotein and glycan cores and play a central role in many biological processes and diseases. Mucins are the most abundant macromolecules in mucus and are responsible for its biochemical and biophysical properties. Mucin-like molecules cover various protozoan parasites, fungi and viruses. In humans, modifications in mucin glycosylation are associated with tumors in epithelial tissue, these modifications allow the distinction between normal and abnormal cell conditions and represent important targets for vaccine development against some cancers. Mucins and mucin-like molecules derived from pathogens are potential diagnostic markers and targets for therapeutic agents. In this review, we summarize the distribution, structure, role as immunomodulators and the correlation of human mucins with diseases, and perform a comparative analysis of mucins with mucin-like molecules present in human pathogens. Furthermore, we review the methods to produce pathogenic and human mucins using chemical synthesis and expression systems. Finally, we present applications of mucin-like molecules in diagnosis and prevention of relevant human diseases.

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Language(s): eng - English
 Dates: 2019-10-092019-10-222019
 Publication Status: Published in print
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Title: Frontiers in Chemistry
  Abbreviation : Front. Chem.
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Media
Pages: - Volume / Issue: 7 Sequence Number: 710 Start / End Page: - Identifier: ISSN: 2296-2646