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  Site‐selective C−H Oxygenation via Aryl Sulfonium Salts

Sang, R., Korkis, S. E., Su, W., Ye, F., Engl, P. S., Berger, F., et al. (2019). Site‐selective C−H Oxygenation via Aryl Sulfonium Salts. Angewandte Chemie, International Edition, 58(45), 16161-16166. doi:10.1002/anie.201908718.

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Genre: Journal Article

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 Creators:
Sang, Ruocheng1, Author              
Korkis, Stamatis E.1, Author              
Su, Wanqi1, Author              
Ye, Fei1, Author              
Engl, Pascal S.1, Author              
Berger, Florian1, Author              
Ritter, Tobias1, Author              
Affiliations:
1Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_2040308              

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Free keywords: C-H functionalization; C-O bond formation; hydroxylation; photo-redox; site-selectivity
 Abstract: Herein, we report a two‐step process forming arene C−O bonds in excellent site‐selectivity at a late‐stage. The C−O bond formation is achieved by selective introduction of a thianthrenium group, which is then converted into C−O bonds using photoredox chemistry. Electron‐rich, ‐poor and ‐neutral arenes as well as complex drug‐like small molecules are successfully transformed into both phenols and various ethers. The sequence differs conceptually from all previous arene oxygenation reactions in that oxygen functionality can be incorporated into complex small molecules at a late stage site‐selectively, which has not been shown via aryl halides.

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Language(s): eng - English
 Dates: 2019-07-132019-09-022019-11-04
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201908718
 Degree: -

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Title: Angewandte Chemie, International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 58 (45) Sequence Number: - Start / End Page: 16161 - 16166 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851