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  International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Nievergelt, C. M., Maihofer, A. X., Klengel, T., Atkinson, E. G., Chen, C.-Y., Choi, K. W., et al. (2019). International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nature Communications, 10(1): 4558. doi:10.1038/s41467-019-12576-w.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-D9CC-2 Version Permalink: https://hdl.handle.net/21.11116/0000-0005-5310-B
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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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Nievergelt, Caroline M., Author
Maihofer, Adam X., Author
Klengel, Torsten, Author
Atkinson, Elizabeth G., Author
Chen, Chia-Yen, Author
Choi, Karmel W., Author
Coleman, Jonathan R. I., Author
Dalvie, Shareefa, Author
Duncan, Laramie E., Author
Gelernter, Joel, Author
Levey, Daniel F., Author
Logue, Mark W., Author
Polimanti, Renato, Author
Provost, Allison C., Author
Ratanatharathorn, Andrew, Author
Stein, Murray B., Author
Torres, Katy, Author
Aiello, Allison E., Author
Almli, Lynn M., Author
Amstadter, Ananda B., Author
Andersen, Søren B., AuthorAndreassen, Ole A., AuthorArbisi, Paul A., AuthorAshley-Koch, Allison E., AuthorAustin, S. Bryn, AuthorAvdibegovic, Esmina, AuthorBabić, Dragan, AuthorBækvad-Hansen, Marie, AuthorBaker, Dewleen G., AuthorBeckham, Jean C., AuthorBierut, Laura J., AuthorBisson, Jonathan I., AuthorBoks, Marco P., AuthorBolger, Elizabeth A., AuthorBørglum, Anders D., AuthorBradley, Bekh, AuthorBrashear, Megan, AuthorBreen, Gerome, AuthorBryant, Richard A., AuthorBustamante, Angela C., AuthorBybjerg-Grauholm, Jonas, AuthorCalabrese, Joseph R., AuthorCaldas- de- Almeida, José M., AuthorDale, Anders M., AuthorDaly, Mark J., AuthorDaskalakis, Nikolaos P., AuthorDeckert, Jürgen, AuthorDelahanty, Douglas L., AuthorDennis, Michelle F., AuthorDisner, Seth G., AuthorDomschke, Katharina, AuthorDzubur-Kulenovic, Alma, AuthorErbes, Christopher R., AuthorEvans, Alexandra, AuthorFarrer, Lindsay A., AuthorFeeny, Norah C., AuthorFlory, Janine D., AuthorForbes, David, AuthorFranz, Carol E., AuthorGalea, Sandro, AuthorGarrett, Melanie E., AuthorGelaye, Bizu, AuthorGeuze, Elbert, AuthorGillespie, Charles, AuthorUka, Aferdita Goci, AuthorGordon, Scott D., AuthorGuffanti, Guia, AuthorHammamieh, Rasha, AuthorHarnal, Supriya, AuthorHauser, Michael A., AuthorHeath, Andrew C., AuthorHemmings, Sian M. J., AuthorHougaard, David Michael, AuthorJakovljevic, Miro, AuthorJett, Marti, AuthorJohnson, Eric Otto, AuthorJones, Ian, AuthorJovanovic, Tanja, AuthorQin, Xue-Jun, AuthorJunglen, Angela G., AuthorKarstoft, Karen-Inge, AuthorKaufman, Milissa L., AuthorKessler, Ronald C., AuthorKhan, Alaptagin, AuthorKimbrel, Nathan A., AuthorKing, Anthony P., AuthorKoen, Nastassja, AuthorKranzler, Henry R., AuthorKremen, William S., AuthorLawford, Bruce R., AuthorLebois, Lauren A. M., AuthorLewis, Catrin E., AuthorLinnstaedt, Sarah D., AuthorLori, Adriana, AuthorLugonja, Bozo, AuthorLuykx, Jurjen J., AuthorLyons, Michael J., AuthorMaples-Keller, Jessica, AuthorMarmar, Charles, AuthorMartin, Alicia R., AuthorMartin, Nicholas G., AuthorMaurer, Douglas, AuthorMavissakalian, Matig R., AuthorMcFarlane, Alexander, AuthorMcGlinchey, Regina E., AuthorMcLaughlin, Katie A., AuthorMcLean, Samuel A., AuthorMcLeay, Sarah, AuthorMehta, Divya, AuthorMilberg, William P., AuthorMiller, Mark W., AuthorMorey, Rajendra A., AuthorMorris, Charles Phillip, AuthorMors, Ole, AuthorMortensen, Preben B., AuthorNeale, Benjamin M., AuthorNelson, Elliot C., AuthorNordentoft, Merete, AuthorNorman, Sonya B., AuthorO’Donnell, Meaghan, AuthorOrcutt, Holly K., AuthorPanizzon, Matthew S., AuthorPeters, Edward S., AuthorPeterson, Alan L., AuthorPeverill, Matthew, AuthorPietrzak, Robert H., AuthorPolusny, Melissa A., AuthorRice, John P., AuthorRipke, Stephan, AuthorRisbrough, Victoria B., AuthorRoberts, Andrea L., AuthorRothbaum, Alex O., AuthorRothbaum, Barbara O., AuthorRoy-Byrne, Peter, AuthorRuggiero, Ken, AuthorRung, Ariane, AuthorRutten, Bart P. F., AuthorSaccone, Nancy L., AuthorSanchez, Sixto E., AuthorSchijven, Dick1, Author           Seedat, Soraya, AuthorSeligowski, Antonia V., AuthorSeng, Julia S., AuthorSheerin, Christina M., AuthorSilove, Derrick, AuthorSmith, Alicia K., AuthorSmoller, Jordan W., AuthorSponheim, Scott R., AuthorStein, Dan J., AuthorStevens, Jennifer S., AuthorSumner, Jennifer A., AuthorTeicher, Martin H., AuthorThompson, Wesley K., AuthorTrapido, Edward, AuthorUddin, Monica, AuthorUrsano, Robert J., Authorvan den Heuvel, Leigh Luella, AuthorVan Hooff, Miranda, AuthorVermetten, Eric, AuthorVinkers, Christiaan H., AuthorVoisey, Joanne, AuthorWang, Yunpeng, AuthorWang, Zhewu, AuthorWerge, Thomas, AuthorWilliams, Michelle A., AuthorWilliamson, Douglas E., AuthorWinternitz, Sherry, AuthorWolf, Christiane, AuthorWolf, Erika J., AuthorWolff, Jonathan D., AuthorYehuda, Rachel, AuthorYoung, Ross McD, AuthorYoung, Keith A., AuthorZhao, Hongyu, AuthorZoellner, Lori A., AuthorLiberzon, Israel, AuthorRessler, Kerry J., AuthorHaas, Magali, AuthorKoenen, Karestan C., Author more..
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1Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands, ou_persistent22              

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 Abstract: The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson’s disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations.

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 Dates: 2019
 Publication Status: Issued
 Pages: -
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-019-12576-w
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 10 (1) Sequence Number: 4558 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723