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  Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes

Spyrou, M. A., Keller, M., Tukhbatova, R. I., Scheib, C. L., Nelson, E. A., Andrades Valtueña, A., et al. (2019). Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes. Nature Communications, 10(1): 4470. doi:10.1038/s41467-019-12154-0.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-D940-F Version Permalink: http://hdl.handle.net/21.11116/0000-0004-D941-E
Genre: Journal Article

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 Creators:
Spyrou, Maria A.1, Author              
Keller, Marcel1, Author              
Tukhbatova, Rezeda I.1, Author              
Scheib, Christiana L., Author
Nelson, Elizabeth A.1, Author              
Andrades Valtueña, Aida1, Author              
Neumann, Gunnar1, Author              
Walker, Don, Author
Alterauge, Amelie, Author
Carty, Niamh, Author
Cessford, Craig, Author
Fetz, Hermann, Author
Gourvennec, Michaël, Author
Hartle, Robert, Author
Henderson, Michael, Author
von Heyking, Kristin, Author
Inskip, Sarah A., Author
Kacki, Sacha, Author
Key, Felix M., Author
Knox, Elizabeth L., Author
Later, Christian, AuthorMaheshwari-Aplin, Prishita, AuthorPeters, Joris, AuthorRobb, John E., AuthorSchreiber, Jürgen, AuthorKivisild, Toomas, AuthorCastex, Dominique, AuthorLösch, Sandra, AuthorHarbeck, Michaela, AuthorHerbig, Alexander1, Author              Bos, Kirsten I.1, Author              Krause, Johannes1, Author               more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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 Abstract: The second plague pandemic, caused by Yersinia pestis, devastated Europe and the nearby regions between the 14th and 18th centuries AD. Here we analyse human remains from ten European archaeological sites spanning this period and reconstruct 34 ancient Y. pestis genomes. Our data support an initial entry of the bacterium through eastern Europe, the absence of genetic diversity during the Black Death, and low within-outbreak diversity thereafter. Analysis of post-Black Death genomes shows the diversification of a Y. pestis lineage into multiple genetically distinct clades that may have given rise to more than one disease reservoir in, or close to, Europe. In addition, we show the loss of a genomic region that includes virulence-related genes in strains associated with late stages of the pandemic. The deletion was also identified in genomes connected with the first plague pandemic (541-750 AD), suggesting a comparable evolutionary trajectory of Y. pestis during both events.

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Language(s): eng - English
 Dates: 2019-10-02
 Publication Status: Published online
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41467-019-12154-0
Other: shh2435
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 10 (1) Sequence Number: 4470 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723