English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Higher fasting ghrelin serum levels in active smokers than in former and never-smokers

Wittekind, D. A., Kratzsch, J., Mergl, R., Enzenbach, C., Witte, A. V., Villringer, A., et al. (2019). Higher fasting ghrelin serum levels in active smokers than in former and never-smokers. The World Journal of Biological Psychiatry. doi:10.1080/15622975.2019.1671610.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0004-DB56-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-E4BB-8
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Wittekind, Dirk Alexander1, Author
Kratzsch, Jürgen2, Author
Mergl, Roland1, 3, Author
Enzenbach, Cornelia4, Author
Witte, A. Veronica5, Author              
Villringer, Arno5, Author              
Kluge, Michael1, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
2Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
3Institute of Clinical Psychology and Psychotherapy, Bundeswehr University Munich, Germany, ou_persistent22              
4Leipzig Research Center for Civilization Diseases (LIFE), University Hospital Leipzig, Germany, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

Content

show
hide
Free keywords: Ghrelin; Nicotine consumption; Addiction; Craving; Population
 Abstract: Objectives: Ghrelin, an orexigenic peptide hormone, promotes drug reward and is suspected to play a role in nicotine dependence. However, there is little data on whether ghrelin levels are associated with active and/or former smoking. The relationship between ghrelin serum levels and smoking status in a population-based sample of individuals was studied. Methods: Total ghrelin was determined after an overnight fast in 1519 subjects participating in a population-based cohort study (‘LIFE-Adult’). Tobacco consumption was assessed using both the questionnaire and interview. Generalised linear models with gamma distribution and log-link function were performed to analyse the association of total serum ghrelin with smoking status and the association between serum ghrelin and the amount of tobacco consumed in active smokers. Results: Ghrelin levels were positively associated with active, but not former smoking (OR = 1.095; p = .002). This association was not moderated by sex (interaction of ‘active smoking’ and sex: p = .346). Ghrelin levels were not associated with the amount of tobacco consumed in active smokers. Conclusions: This study provides evidence that total ghrelin serum levels are positively associated with active smoking. No association was found for former smokers. A unique feature of the study is the large sample size.

Details

show
hide
Language(s): eng - English
 Dates: 2019-01-152019-09-252019-10-04
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1080/15622975.2019.1671610
Other: Epub ahead of print
PMID: 31552785
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : 100094348
Funding program : -
Funding organization : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig
Project name : -
Grant ID : -
Funding program : -
Funding organization : European Union (EU)
Project name : -
Grant ID : -
Funding program : European Social Fund (ESF)
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : European Regional Development Fund (ERDF)
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Free State of Saxony

Source 1

show
hide
Title: The World Journal of Biological Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Abingdon : Taylor & Francis
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1562-2975
ISSN: 1814-1412