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  Higher fasting ghrelin serum levels in active smokers than in former and never-smokers

Wittekind, D. A., Kratzsch, J., Mergl, R., Enzenbach, C., Witte, A. V., Villringer, A., et al. (2020). Higher fasting ghrelin serum levels in active smokers than in former and never-smokers. The World Journal of Biological Psychiatry, 21(10), 748-756. doi:10.1080/15622975.2019.1671610.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-DB56-5 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-E88C-3
Genre: Journal Article

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 Creators:
Wittekind, Dirk Alexander1, Author
Kratzsch, Jürgen2, Author
Mergl, Roland1, 3, Author
Enzenbach, Cornelia4, Author
Witte, A. Veronica5, Author           
Villringer, Arno5, Author           
Kluge, Michael1, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
2Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
3Institute of Clinical Psychology and Psychotherapy, Bundeswehr University Munich, Germany, ou_persistent22              
4Leipzig Research Center for Civilization Diseases (LIFE), University Hospital Leipzig, Germany, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Ghrelin; Nicotine consumption; Addiction; Craving; Population
 Abstract: Objectives: Ghrelin, an orexigenic peptide hormone, promotes drug reward and is suspected to play a role in nicotine dependence. However, there is little data on whether ghrelin levels are associated with active and/or former smoking. The relationship between ghrelin serum levels and smoking status in a population-based sample of individuals was studied.
Methods: Total ghrelin was determined after an overnight fast in 1519 subjects participating in a population-based cohort study (‘LIFE-Adult’). Tobacco consumption was assessed using both the questionnaire and interview. Generalised linear models with gamma distribution and log-link function were performed to analyse the association of total serum ghrelin with smoking status and the association between serum ghrelin and the amount of tobacco consumed in active smokers.
Results: Ghrelin levels were positively associated with active, but not former smoking (OR = 1.095; p = .002). This association was not moderated by sex (interaction of ‘active smoking’ and sex: p = .346). Ghrelin levels were not associated with the amount of tobacco consumed in active smokers.

Conclusions: This study provides evidence that total ghrelin serum levels are positively associated with active smoking. No association was found for former smokers. A unique feature of the study is the large sample size.

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Language(s): eng - English
 Dates: 2019-01-152019-09-252019-10-042020-12
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1080/15622975.2019.1671610
Other: Epub 2019
PMID: 31552785
 Degree: -

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Project name : -
Grant ID : 100094348
Funding program : -
Funding organization : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig
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Grant ID : -
Funding program : -
Funding organization : European Union (EU)
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Funding program : European Social Fund (ESF)
Funding organization : European Commission (EC)
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Funding program : European Regional Development Fund (ERDF)
Funding organization : European Commission (EC)
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Grant ID : -
Funding program : -
Funding organization : Free State of Saxony

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Title: The World Journal of Biological Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Abingdon : Taylor & Francis
Pages: - Volume / Issue: 21 (10) Sequence Number: - Start / End Page: 748 - 756 Identifier: ISSN: 1562-2975
ISSN: 1814-1412