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  Aldehydes as Alkylating Agents for Ketones

Runikhina, S. A., Afanasyev, O. I., Biriukov, K., Perekalin, D. S., Klussmann, M., & Chusov, D. (2019). Aldehydes as Alkylating Agents for Ketones. Chemistry – A European Journal, 25(71), 16225-16229. doi:10.1002/chem.201904605.

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 Creators:
Runikhina, Sofiya A.1, Author
Afanasyev, Oleg I.1, Author
Biriukov, Klim1, Author
Perekalin, Dmitry S.1, 2, Author
Klussmann, Martin3, Author           
Chusov, Denis1, 2, Author
Affiliations:
1Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova St. 28, 119991 Moscow, Russia, ou_persistent22              
2G.V. Plekhanov Russian University of Economics, 36 Stremyanny Per., 117997 Moscow, Russia, ou_persistent22              
3Research Group Klußmann, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445608              

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Free keywords: aldehydes; alpha-alkylation; ketones; reductive coupling; ruthenium
 Abstract: Common and non‐toxic aldehydes are proposed as reagents for alkylation of ketones instead of carcinogenic alkyl halides. The developed reductive alkylation reaction proceeds in the presence of the commercially available ruthenium catalyst [(cymene)RuCl2]2 (as low as 250 ppm) and carbon monoxide as the reducing agent. The reaction works well for a broad substrate scope, including aromatic and aliphatic aldehydes and ketones. It can be carried out without a solvent and often gives nearly quantitative yields of the products. This straightforward and cost‐effective method is promising not only for laboratory application but also for industry, which produces carbon monoxide as a large‐scale waste product.

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Language(s): eng - English
 Dates: 2019-10-082019-10-112019-12-18
 Publication Status: Published online
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/chem.201904605
 Degree: -

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Title: Chemistry – A European Journal
  Other : Chem. – Eur. J.
  Other : Chem. Eur. J.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 25 (71) Sequence Number: - Start / End Page: 16225 - 16229 Identifier: ISSN: 0947-6539
CoNE: https://pure.mpg.de/cone/journals/resource/954926979058