Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients

Hankir, M. K., Rullmann, M., Seyfried, F., Preusser, S., Poppitz, S., Heba, S., et al. (2019). Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients. JCI Insight, 4(19): e131329. doi:10.1172/jci.insight.131329.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
Hankir_2019.pdf (Verlagsversion), 4MB
Name:
Hankir_2019.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Hankir, Mohammed K.1, Autor
Rullmann, Michael2, 3, 4, 5, Autor           
Seyfried, Florian6, Autor
Preusser, Sven4, Autor           
Poppitz, Sindy2, 4, Autor
Heba, Stefanie7, Autor
Gousias, Konstantinos8, Autor
Hoyer, Jana9, Autor
Schütz, Tatjana2, Autor
Dietrich, Arne2, 10, Autor
Mueller, Karsten11, Autor           
Pleger, Burkhard2, 4, 5, 7, Autor           
Affiliations:
1Department of Surgery, University Hospital Würzburg, Germany, ou_persistent22              
2Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
3Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
5Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
6Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Germany, ou_persistent22              
7Department of Neurology, University Hospital Bergmannsheil, Bochum, Germany, ou_persistent22              
8Department of Neurosurgery, University Hospital Bergmannsheil, Bochum, Germany, ou_persistent22              
9Department of Behavioral Epidemiology, TU Dresden, Germany, ou_persistent22              
10Department of Bariatric Surgery, University Hospital Leipzig, Germany, ou_persistent22              
11Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Metabolism; Neuroimaging; Neuroscience; Obesity
 Zusammenfassung: There is increased interest in whether bariatric surgeries such as Roux-en-Y gastric bypass (RYGB) achieve their profound weight-lowering effects in morbidly obese individuals through the brain. Hypothalamic inflammation is a well-recognized etiologic factor in obesity pathogenesis and so represents a potential target of RYGB, but clinical evidence in support of this is limited. We therefore assessed hypothalamic T2-weighted signal intensities (T2W SI) and fractional anisotropy (FA) values, 2 validated radiologic measures of brain inflammation, in relation to BMI and fat mass, as well as circulating inflammatory (C-reactive protein; CrP) and metabolic markers in a cohort of 27 RYGB patients at baseline and 6 and 12 months after surgery. We found that RYGB progressively increased hypothalamic T2W SI values, while it progressively decreased hypothalamic FA values. Regression analyses further revealed that this could be most strongly linked to plasma CrP levels, which independently predicted hypothalamic FA values when adjusting for age, sex, fat mass, and diabetes diagnosis. These findings suggest that RYGB has a major time-dependent impact on hypothalamic inflammation status, possibly by attenuating peripheral inflammation. They also suggest that hypothalamic FA values may provide a more specific radiologic measure of hypothalamic inflammation than more commonly used T2W SI values.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2019-08-292019-10-03
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1172/jci.insight.131329
PMID: 31465301
PMC: PMC6795400
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden: ausblenden:
Projektname : -
Grant ID : 01E01001
Förderprogramm : -
Förderorganisation : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
Projektname : Obesity Mechanisms / SFB 1052
Grant ID : -
Förderprogramm : -
Förderorganisation : German Research Foundation (DFG)
Projektname : Integration and Representation of Sensory Processes / SFB 874
Grant ID : -
Förderprogramm : -
Förderorganisation : German Research Foundation (DFG)

Quelle 1

einblenden:
ausblenden:
Titel: JCI Insight
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Ann Arbor : American Society for Clinical Investigation (ASCI)
Seiten: - Band / Heft: 4 (19) Artikelnummer: e131329 Start- / Endseite: - Identifikator: ISSN: 2379-3708
CoNE: https://pure.mpg.de/cone/journals/resource/2379-3708