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  Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients

Hankir, M. K., Rullmann, M., Seyfried, F., Preusser, S., Poppitz, S., Heba, S., et al. (2019). Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients. JCI Insight, 4: 19. doi:10.1172/jci.insight.131329.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-DD37-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-E4B6-D
Genre: Journal Article

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 Creators:
Hankir, Mohammed K.1, Author
Rullmann, Michael2, 3, 4, 5, Author              
Seyfried, Florian6, Author
Preusser, Sven4, Author              
Poppitz, Sindy2, 4, Author
Heba, Stefanie7, Author
Gousias, Konstantinos8, Author
Hoyer, Jana9, Author
Schütz, Tatjana2, Author
Dietrich, Arne2, 10, Author
Mueller, Karsten11, Author              
Pleger, Burkhard2, 4, 5, 7, Author              
Affiliations:
1Department of Surgery, University Hospital Würzburg, Germany, ou_persistent22              
2Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
3Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
5Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
6Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Würzburg, Germany, ou_persistent22              
7Department of Neurology, University Hospital Bergmannsheil, Bochum, Germany, ou_persistent22              
8Department of Neurosurgery, University Hospital Bergmannsheil, Bochum, Germany, ou_persistent22              
9Department of Behavioral Epidemiology, TU Dresden, Germany, ou_persistent22              
10Department of Bariatric Surgery, University Hospital Leipzig, Germany, ou_persistent22              
11Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

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Free keywords: Metabolism; Neuroimaging; Neuroscience; Obesity
 Abstract: There is increased interest in whether bariatric surgeries such as Roux-en-Y gastric bypass (RYGB) achieve their profound weight-lowering effects in morbidly obese individuals through the brain. Hypothalamic inflammation is a well-recognized etiologic factor in obesity pathogenesis and so represents a potential target of RYGB, but clinical evidence in support of this is limited. We therefore assessed hypothalamic T2-weighted signal intensities (T2W SI) and fractional anisotropy (FA) values, 2 validated radiologic measures of brain inflammation, in relation to BMI and fat mass, as well as circulating inflammatory (C-reactive protein; CrP) and metabolic markers in a cohort of 27 RYGB patients at baseline and 6 and 12 months after surgery. We found that RYGB progressively increased hypothalamic T2W SI values, while it progressively decreased hypothalamic FA values. Regression analyses further revealed that this could be most strongly linked to plasma CrP levels, which independently predicted hypothalamic FA values when adjusting for age, sex, fat mass, and diabetes diagnosis. These findings suggest that RYGB has a major time-dependent impact on hypothalamic inflammation status, possibly by attenuating peripheral inflammation. They also suggest that hypothalamic FA values may provide a more specific radiologic measure of hypothalamic inflammation than more commonly used T2W SI values.

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Language(s): eng - English
 Dates: 2019-08-292019-10-03
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1172/jci.insight.131329
PMID: 31465301
 Degree: -

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Project name : -
Grant ID : 01E01001
Funding program : -
Funding organization : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
Project name : Obesity Mechanisms / SFB 1052
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : Integration and Representation of Sensory Processes / SFB 874
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)

Source 1

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Title: JCI Insight
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Ann Arbor : American Society for Clinical Investigation (ASCI)
Pages: - Volume / Issue: 4 Sequence Number: 19 Start / End Page: - Identifier: ISSN: 2379-3708
CoNE: https://pure.mpg.de/cone/journals/resource/2379-3708