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  Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture

Chandler, D., Jensen, P., McCall, J., Pickering, A., Schwarz, L., & Totah, N. (2019). Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture. The Journal of Neuroscience, 39(42), 8239-8249. doi:10.1523/JNEUROSCI.1164-19.2019.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-DD69-E Version Permalink: http://hdl.handle.net/21.11116/0000-0004-DD6A-D
Genre: Journal Article

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 Creators:
Chandler, DJ, Author
Jensen , P, Author
McCall, JG, Author
Pickering, AE, Author
Schwarz, LA, Author
Totah, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: The locus coeruleus (LC) is a seemingly singular and compact neuromodulatory nucleus that is a prominent component of disparate theories of brain function due to its broad noradrenergic projections throughout the CNS. As a diffuse neuromodulatory system, noradrenaline affects learning and decision making, control of sleep and wakefulness, sensory salience including pain, and the physiology of correlated forebrain activity (ensembles and networks) and brain hemodynamic responses. However, our understanding of the LC is undergoing a dramatic shift due to the application of state-of-the-art methods that reveal a nucleus of many modules that provide targeted neuromodulation. Here, we review the evidence supporting a modular LC based on multiple levels of observation (developmental, genetic, molecular, anatomical, and neurophysiological). We suggest that the concept of the LC as a singular nucleus and, alongside it, the role of the LC in diverse theories of brain function must be reconsidered.

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 Dates: 2019-10
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1523/JNEUROSCI.1164-19.2019
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Title: The Journal of Neuroscience
  Other : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
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Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: 39 (42) Sequence Number: - Start / End Page: 8239 - 8249 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1